Translation of Journal of Cell Science

Prosser, D. C., et al.
"FFAT Rescues VAPA-Mediated Inhibition of ER-to-Golgi
Transport and VAPB-Mediated ER Aggregation."
Journal of Cell Science, vol. 121, no. 18, 19 June 2008, pp. 3052-3061.,
doi:10.1242/jcs.028696.

(Translated by Sohail Syed)

Support

VAP (VAMP (Vesicle-associated membrane protein) Associated Proteins)

A small gene family that are characterized by the presence of a N-terminal MSP domain

https://www.ebi.ac.uk/interpro/entry/IPR016763

MSP domain (Major Sperm Protein)

molecular complexes that help cell motility

https://www.sciencedirect.com/science/article/pii/S1471492205000747

P56S mutation

The mutation of the B isoform of VAP that is linked to ALS8

http://www.jbc.org/content/281/40/30223.long

FFAT motif (Two Phenylalanines in an Acidic Tract)

Amino Acid sequence that often bind with VAPs in order to help with cellular function

https://www.ncbi.nlm.nih.gov/pubmed/16004875

Immobile obstacles

Immovable structures within the ER that make lateral diffusion and mobility harder for protein structures

https://www.sciencedirect.com/science/article/pii/S0006349505732513

Links for paper

Paper

https://www.semanticscholar.org/paper/FFAT-rescues-VAPA-mediated-inhibition-of-transport-Prosser-Tran/9b13eb7502624dfc624d746bfa1d31714a3c9eb9

Paper with Supplementary Info

http://jcs.biologists.org/content/121/18/3052.long