VAP (VAMP (Vesicle-associated membrane protein) Associated Proteins)
A small gene family that are characterized by the presence of a N-terminal MSP domain
https://www.ebi.ac.uk/interpro/entry/IPR016763
MSP domain (Major Sperm Protein)
molecular complexes that help cell motility
https://www.sciencedirect.com/science/article/pii/S1471492205000747
P56S mutation
The mutation of the B isoform of VAP that is linked to ALS8
http://www.jbc.org/content/281/40/30223.long
FFAT motif (Two Phenylalanines in an Acidic Tract)
Amino Acid sequence that often bind with VAPs in order to help with cellular function
https://www.ncbi.nlm.nih.gov/pubmed/16004875
Immobile obstacles
Immovable structures within the ER that make lateral diffusion and mobility harder for protein structures
https://www.sciencedirect.com/science/article/pii/S0006349505732513
Links for paper
Paper
Paper with Supplementary Info