Home Abstract Introduction
Immunofluorescence of VAPs and Calreticulin Time Course Immunofluorescence of VSVG with relationship to the FFAT motif Immunofluorescence of Calreticulin and Chromogranin B Time Course Immunofluorescence of properly folded VSVG Quantitative Western Immunoblot of VSVG for ER budding Western Blots and Quantification of Microtubule binding of FFAT and AAAT
Implications Support

Translation of Journal of Cell Science

Prosser, D. C., et al.
"FFAT Rescues VAPA-Mediated Inhibition of ER-to-Golgi
Transport and VAPB-Mediated ER Aggregation."
Journal of Cell Science, vol. 121, no. 18, 19 June 2008, pp. 3052-3061.,
doi:10.1242/jcs.028696.

(Translated by Sohail Syed)

Implications

With the onset of ALS8 in patients it was proposed to synthesize the FFAT peptide into a deliverable treatment. The process would specifically target affected cells and hopefully alleviate neuron deterioration. This was proposed as a possible treatment/therapeutic option for patients with ALS8. Although this method has not been made possible yet, this research enables treatment companies to see the practicality and possibility of the FFAT motif becoming a cure for the sudden onset of ALS8.