Since magnitude of glutamate depends on frequency of stimulation, neighboring cells may be able to respond to the frequency at which a nerve is firing.]
Hires SA, Zhu Y, Tsien R (2008)
Optical measurement of synaptic glutamate spillover and reuptake
by linker optimized glutamate-sensitive fluorescent reporters
Proc Natl Acad Sci USA 105:4411-4416
Optical measurement of synaptic glutamate spillover and reuptake
by linker optimized glutamate-sensitive fluorescent reporters
Proc Natl Acad Sci USA 105:4411-4416
(Translated by Jeff Elhai)
Implications: Glutamate function
[Glutamate concentration rises rapidly at surface of dendrite and disappears rapidly – 10’s of milliseconds-- unless reuptake inhibited.
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