Home Abstract Introduction
Detection of the S. pneumoniae Interactome Determination of the Orthologous Sequences Functional Prediction of Unknown Proteins in S. pneumoniae Enrichment of Accuracy as a Function of Degree Heterogeneity of Functional Prediction
Conservation of Protein Functions
Yeast Two-Hybrid Protocol Orthologous Determination via InParanoid Simpson's S Index

Journal of Comprehensible Results

Wuchty, S., Rajagopala, S. V., Blazie, S. M., Parrish, J. R., Khuri, S., Finley, R. L., & Uetz, P. (2017).
The Protein Interactome of Streptococcus pneumoniae and Bacterial
meta-interactomes Improve Function Predictions
DOI: 10.1128/mSystems.00019-17

Translated by Farhana Khan

Significance

The article focuses on the observations of the protein networks in Pneumococcal disease (pneumonia), which is caused by the bacterial strain Streptococcus pneumoniae. These bacteria can cause many types of illnesses in humans, such as pneumonia, ear infections, sinus infections, etc. This can be spread through coughing, sneezing, and ultimately any close contact with an infected person.

This experiment focused on S. pneumoniae since little information is given to understand this bacterial strain and the relationship between its proteins. Observations of the patterns and dynamic of protein networks is used in order to map the interactions between its proteins as well.

Table of Contents

Fig 1. Image of the Pneumococcus bacteria Streptococcus pneumoniae. Example of a protein interactome, with lines determining the interactions that occur between the genes provided.