Home Abstract Introduction
Detection of the S. pneumoniae Interactome Determination of the Orthologous Sequences Functional Prediction of Unknown Proteins in S. pneumoniae Enrichment of Accuracy as a Function of Degree Heterogeneity of Functional Prediction
Conservation of Protein Functions
Yeast Two-Hybrid Protocol Orthologous Determination via InParanoid Simpson's S Index

Journal of Comprehensible Results

Wuchty, S., Rajagopala, S. V., Blazie, S. M., Parrish, J. R., Khuri, S., Finley, R. L., & Uetz, P. (2017).
The Protein Interactome of Streptococcus pneumoniae and Bacterial
meta-interactomes Improve Function Predictions
DOI: 10.1128/mSystems.00019-17

Translated by Farhana Khan

Implication 1: Conservation of protein functions

Ultimately the experiment was able to compile a quality interactome of the bacterial strain S. pneumoniae by obtaining information and data sets of evolutionarily conserved bacteria that share commons ancestors with this strain. The conclusion can be made that the known proteins in S. pneumoniae can be used in order to determine unknown functions in other strains as well, if it supports the definition of being an orthologous function.

In total, the meta-interactome created included a little over 2,000 PPIs with about 1300 of them being functionally predicted proteins.