Biol 591
Introduction to Bioinformatics
Fall 2003
August
September
October
November
December
Monday
Wednesday
Friday
1: NO CLASS
(but consultations highly encouraged)
3:
Scenario 3: Sequence alignment
Introduction:
The story
Questionnaire
(
HTML
)
Exam 1 due
6:
Scenario 3: Sequence alignment
Notes
-
DNA Alignment
Questionnaire
(
HTML
)
8:
Scenario 3: Sequence alignment
Notes
-
2D-arrays and BlastN
Questionnaire
(
HTML
)
10:
Scenario 3: Sequence alignment
Notes
-
Scoring/Protein Alignment
Questionnaire
(
HTML
)
13:
Scenario 3: Sequence alignment
Notes
-
Scoring/Protein Alignment
Notes-
What's wrong with
BlastN
?
Questionnaire
(
HTML
)
15:
Scenario 4: Metabolic modeling
Introduction:
The story
Scenario 3: Sequence alignment
Problem Set 3
: Focus on 5, 8, 7, 2
17:
Scenario 4: Metabolic modeling
Notes-
Metabolic Modeling
Read
Eisenthal & Cornish-Bowden (1998)
Questionnaire
(
HTML
)
20:
Scenario 4: Metabolic modeling
Notes-
Modeling program
Questionnaire
(
HTML
)
22:
Scenario 5: Position-specific Scoring Matrices
Introduction:
The story
Scenario 4: Metabolic modeling
Problem Set 4
: Focus on 3, 6, 10
24:
Scenario 5: PSSMs
Notes-
PSSMs
Questionnaire
(
HTML
)
27:
Scenario 5: PSSMs
Notes-
PSSM-program
Questionnaire
(
HTML
)
Self-critique of Exam 1 due
Problem sets 3 and 4 due
29:
Scenario 5: PSSMs
Problem Set 5
: Focus on 4, 6, 8, 10
31:
General Discussion of
Problems/Study Questions
Your choice! (
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Exam 2 available at end of class