Study Guide for Your Final Exam
MoAbs and 99mTc
- What is a Moab?
- How do they differ?
- What makes them work?
- What is the process of creating a Moab?
- What are the difference between fragmented and whole MoAbs?
- Why is there so much liver uptake in most procedures?
- From a diagnostic and therapeutic standpoints, what type of radionuclide would you label these MoAbs to?
- Consider the following terms:
- Mono vs Polyclonal
- IgG and its structure
- HAMA and its response
- Affinity and Avidity
- Immunoreactive fraction and immunospecificity
- Related to MoAb imaging know the following
- Gleason score/sum
- PSA levels, density, TRUS, and velocity
- CEA levels and Duke's Classification
- Given a mCi values determine the correction factor of a pure beta emitter when applying a dose calibrator
- Evaluate the ProstaScint procedure (detail) and discuss its relationship to other diagnostic procedures in imaging
- Evaluate the different treatment options available for prostate cancer
- Regarding Bexxar and Zevalin
- Discuss the B-lymphocyte life cycle and where Ca enters into it
- How does a slow vs. fast clearance effect the dose administered?
- What is the role of the pre-dosing (prior to the administration of any radiomoAb)?
- Understand the complete dosing regiment/time line
- When imaging these agents, what abnormalities prevents the therapy from being administered?
- How would you imagine these agents (131I and 111In)
- How effective are they in treating disease?
- Understand the pathophysiology of 99mTcO4-
- VP vs. IF
- Distribution in the GI track, kidney. thyroid, sweat glands, and brain
- How does the body reduce the biological half-life of this agent?
From Exam I - A Little Bit of This and a Little Bit of That
- Understand the basic procedures from the following: vascular analysis of disease, lymphoscintigraphy, bone palliation, infectious imaging with labeled WBCs/Ga67, mammoscintigraphy, testicular, La Veen Shunt, CSF Shunt, Salivary, La Veen Shunt, Dacro imaging, H. Pylori Breath Test, Bone Marrow Imaging, Pulmonary aspiration
- From question 1, know the pathophysiology associated with the appropriate radiopharmaceutical
- From question 1, know the diagnostic potential for each procedure and what is considered normal/abnormal
- From question 1, know the diseases associated with each procedure
- Special applications should be understood
with certain procedures
- Using a lemon
- Clapper Bell vs. Epididymitis vs. Varicocele vs. Hydrocele
- Digital massage
- Uptake and washout are the two predictors
- Shunt patency and organ uptake
- Compare Ga67 to In111/Tc99mWBCs
- How are In111WBCs images normalized with Tc99mMDP images
- Compare Sr89 to Sm153
- How are dynamic nuclear medicine procedures used to diagnose disease
- The cause of epiphora
- Who gets H. Pylori and how is it detected
- Imaging the marrow with Fe, In, or SC
- Aspiration in kids and adults
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