Publications
Seegar, T.C.M., Eller, B., Tzvetkova-Robev, D., Kolev, M.V., Henderson, S.C., Nikolov, D.B., Barton, W.A. (2010) Tie1-Tie2 Interactions mediate functional differencesbetween angiopoietin ligands. Molecular Cell 37: 643-655.
Barton, W.A., Tzvetkova-Robev, D., Miranda, E.P., Kolev, M.V., Rajashankar, K.R., Himanen, J.P., Nikolov, D.B. (2006) Crystal structures of the Tie2 ectodomain and the Angiopoietin-2/Tie2 complex. Nature Structural and Molecular Biology 13(6): 524-532.
Barton, W.A., Tzvetkova-Robev, D., Erdjument-Bromage, H., Tempst, P., Nikolov, D.B. (2006) Highly efficient seleno-methionine labeling of recombinant proteins produced in mammalian cells. Protein Science 15(8): 2008-2013.
Janes, P.W., Saha, N., Barton, W.A., Kolev, M.V., Wimmer-Kleikamp, S.H., Nievergall, E., Blobel, C.P., Himanen, J.P., Lackmann, M., Nikolov, D.B. (2005) Adam meets Eph: The structure of the ADAM10 substrate-recognition module reveals a molecular switch regulating ephrin cleavage. Cell 123(2): 291-304.
Himanen, J.P., Li, C., Barton, W.A., Nikolov, D.B. (2005) Crystal structure of the Ephrin-B1 ecto-domain: Implications for receptor recognition and signaling. Biochemistry 44(33): 10947-10953.
Barton, W.A., Himanen, J.P., Antipenko, A., Nikolov, D.B. (2004) Structures of axon guidance molecules and their neuronal receptors. Advances in Protein Chemistry 68:65-106.
Barton, W.A., Tzvetkova, D., Kolev, M., Nikolov, D.B. (2005) Structure of the Angiopoietin-2 receptor-binding domain and identification of surfaces involved in Tie2 recognition. Structure 13(5)825-832.
Barton, W.A., Tzvetkova, D., Nikolov, D.B. An efficient protocol for labeling proteins with seleno-methionine in mammalian tissue culture. [In Preparation].
Himanen, J.P., Chumley, M.J., Lackman, M., Li, C., Barton, W.A., Jeffrey, P.D., Vearing, C., Geleick, D., Feldheim, D.A., Boyd, A.W., Henkemeyer, M., Nikolov, D.B. (2004). Repelling class discrimination: EphrinA5 binds to and activates EphB2 receptor signaling. Nature Neuroscience 7(5): 501-509.
Thorson, J.S., Barton, W.A., Hoffmeister, D., Albermann, C., Nikolov, D.B. (2004). Structure based engineering and its impact on in vitro glycorandomization. ChemBioChem 5(1): 16-25.
Antipenko, A., Himanen, J.-P., van Leyen, K., Nardi-Dei, V., Lesniak, J., Barton, W.A., Rajashankar, K.R., Lu, M., Hoemme, C., Puschel, A.W., Nikolov, D.B. (2003). Structure of the Semaphorin-3A receptor-binding module. Neuron 39(4): 589-598.
Barton, W.A., Liu, B.P., Tzvetkova, D., Jeffrey, P.D., Fournier, A.E., Sah, D., Cate, R., Strittmatter, S.M., Nikolov, D.B. (2003). Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO Journal 22(13): 3291-3302.
Lesniak, J., Barton, W.A., Nikolov, D.B. (2003). Structure and functional features of the Escherichia coli hydroperoxide resistance protein OsmC. Protein Science 12(12): 2838-2843.
Albermann, C., Soriano, A., Jiang, J., Vollmer, H., Biggins, J.B., Barton, W.A., Lesniak, J., Nikolov, D.B., Thorson, J.S. (2003). Substrate specificty of NovM: Implications for novobiocin biosynthesis and glycorandomization. Organic Letters 5(6): 933-936.
Lesniak, J., Barton, W.A., Nikolov, D.B. (2002). Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr. EMBO Journal 21(24): 6649-6659.
Barton, W.A., Biggins, J.B., Jiang, J., Thorson, J.S., Nikolov, D.B. (2002). Expanding pyrimidine diphosphosugar libraries via structure based nucleotidylyltransferase engineering. Proceedings of the National Academy of Sciences USA 99(21): 13397-13402.
Barton, W.A., Lesniak, J., Biggins, J.B., Jeffrey, P.D., Jiang, J., Rajashankar, K.R., Thorson, J.S., Nikolov, D.B. (2001). Structure, mechanism, and engineering of a nucleotidylyltransferase as a first step toward glycorandomization. Nature Structural Biology 8(6): 545-551.
Garrett S., Barton W.A., Knights R., Jin P., Morgan D.O., Fisher R.P. (2001). Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Molecular and Cellular Biology 21(1): 88-99.
Lee, K.M., Saiz, J.E., Barton, W.A., Fisher, R.P. (1999). Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs). Current Biology 9: 441- 444.