Ceramide-1-phosphate derived specifically from ceramide kinase demonstrated a large role in the proper eicosanoid response after mechanical trauma. The addition of ceramide-1-phosphate from mechanisms not catalyzed by ceramide kinase would not account for the role that ceramide kinase plays in fibroblast migration. It may be important to investigate the role of this enzyme in the functions of cell types other than fibroblasts in the process of wound healing, since there are many other cell types involved in such a complex process like this one. Other cell types might even include epithelial cells, which are the cells that migrate to the wound site soon after fibroblasts do as mentioned in the significance section.

Why is this important? Why does it matter if these enzymes facilitate such processes and that the appropriate cells migrate properly? Improper migration of fibroblasts or even abnormal increases in migration may lead to the uneven placement of collagen on the extracellular matrix created by these fibroblasts. If the collagen is uneven, the strength of these wounds is affected and the appearance of these wounds would be different than it would have been if it were healed normally. Scar formation is common when the collagen is unevenly distributed. Fibroblast migration inhibition would also have an effect on the wound. The fibroblasts would stay near the margins of the found, unable to create the extracellular matrix of collagen. Without this extracellular matrix, the induction of the other cell types to the wound is then affected as well. A detrimental effect improper fibroblast migration may have on the body is the onset of disease. These diseases do not only occur from the fibroblast migration during wound healing, but rather any kind of abnormality in the migration and growth of these cells can have this effect. Further investigation on the effects of ceramide kinase on such cells may improve the chances for treatment of related disorders.