Multi-disciplinary
Rational
Drug Design
Our research focuses on the medicinal
chemistry of small and large molecules that have sulfate functionalities. These
molecules are novel for several reasons. They possess unique biophysical and
chemical properties. They are soluble in water. They bind many different types
of biological molecules.
We design, synthesize and
study the molecular interactions of these molecules. Rational design utilizes
computerized molecular modeling, synthesis uses traditional organic and parallel
combinatorial approaches, while investigation of their biophysical
and biochemical properties utilizes fluorescence, NMR, rapid and slow kinetic
techniques.
In combination, our
laboratory explores several inter-disciplinary areas at the interface of
chemistry and biology.
At the present time, the major
projects in the laboratory are :
Click on the hyperlinks
above or below to learn more about our research
[home] [school
of pharmacy] [department of medicinal
chemistry]
[links to sites of interest and download center] [instructions
for downloading and installing software]
©2003 VCU School of Pharmacy
Revised: March 10, 2003
Questions or Comments : Dr. Umesh
R. Desai