Our Publications

Research Articles
  1. Capillary electrophoretic study of small, highly sulfated, non-sugar molecules interacting with antithrombin. A Liang, A Raghuraman and UR Desai (2009) Electrophoresis (in press). [pdf]
  2. On designing non-saccharide, allosteric activators of antithrombin. A Raghuraman, A Liang, C Krishnasamy, T Lauck, GT Gunnarsson and UR Desai (2009) Eur. J. Med. Chem. (in press). [pdf]
  3. Characterization of the plasma and blood anticoagulant potential of structurally and mechanistically novel oligomers of 4-hydroxycinnamic acids. BL Henry, JN Thakkar, EJ Martin, DF Brophy and UR Desai (2009) Blood Coagulation and Fibrinolysis (in press). [pdf]
  4. Application of molecular connectivity and electro-topological indices in quantitative structure activity analysis of pyrazole derivatives as inhibitors of factor Xa and thrombin. C Krishnasamy, A Raghuraman, LB Kier and UR Desai (2009) Chemistry and Biodiversity (in press). [pdf]
  5. Recent research developments in the direct inhibition of coagulation proteinases ¾ Inhibitors of the initiation phase. BL Henry and UR Desai (2008) Cardiovascular and Haematological Agents in Medicinal Chemistry 6, 323-336. [pdf]
  6. A capillary electrophoretic method for fingerprinting low molecular weight heparins. JT King and UR Desai (2008) Analytical Biochemistry  280, 229-234. [pdf]
  7. A novel allosteric pathway of thrombin inhibition. Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids. BL Henry, BH Monien, PE Bock and UR Desai (2007) Journal of Biological Chemistry 282, 31891-31899. [pdf]
  8. Rapid, high-yielding microwave-assisted per-sulfation of organic scaffolds. A Raghuraman, M Riaz, M Hindle and UR Desai (2007) Tetrahedron Letters 48, 6754-6758. [pdf]
  9. Synthesis of biologically relevant bi-flavanoids – a review. M Rahman, M Riaz and UR Desai (2007) Chemistry and Biodiversity 4, 2495-2527. [pdf]
  10. Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate. A Raghuraman, V Tiwari, Q Zhao, D Shukla, AK Debnath and UR Desai (2007) Biomacromolecules 8, 1759-1763. [pdf]
  11. Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases; BH Monien, BL Henry, A Raghuraman, M Hindle and UR Desai (2006) Bioorganic and Medicinal Chemistry 14, 7988-7998. [pdf]
  12. Finding needle in a haystack. Development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence(s). A Raghuraman, PD Mosier and UR Desai (2006) Journal of Medicinal Chemistry 49, 3553-3562. [pdf]
  13. Importance of tryptophan 49 of antithrombin in heparin binding and conformational activation; BH Monien C Krishnasamy, ST Olson, and UR Desai (2005) Biochemistry 44, 11660-11668. [pdf]
  14. Structural characterization of a serendipitously discovered bioactive macromolecule, lignin sulfate; A Raghuraman, V Tiwari, JN Thakkar, GT Gunnarsson, D Shukla, M Hindle and UR Desai (2005) Biomacromolecules 6, 2822-2832. [pdf]
  15. Mechanism of poly(acrylic acid) acceleration of antithrombin inhibition of thrombin: Implications for the design of novel heparin mimics; BH Monien, KI Cheang and UR Desai (2005) Journal of Medicinal Chemistry 48, 5360-5368. [pdf]
  16. Antithrombin activation by non-sulfated, non-polysaccharide organic polymer; BH Monien and UR Desai (2005) Journal of Medicinal Chemistry 48, 1269-1273. [pdf]
  17. Synthesis of per-sulfated flavonoids using 2,2,2-trichloro ethyl protecting group and their factor Xa inhibition potential; GT Gunnarsson, M Riaz, J Adams and UR Desai (2005) Bioorganic and Medicinal Chemistry 13, 1783-1789. [pdf]
  18. Capillary electrophoresis of highly sulfated flavanoids and flavonoids; M Dantuluri, GT Gunnarsson, M Riaz, H Nguyen and UR Desai (2005) Analytical Biochemistry 336, 316-322. [pdf]
  19. 1,2-Dithiole-3-ones as potent inhibitors of bacterial 3-ketoacyl acyl carrier protein synthases III; Xin He, Anne Reeve, UR Desai, GE Kellogg, and KA Reynolds (2004) Antimicrobial Agents and Chemotherapy 48, 3093-3102. [pdf]
  20. Hydropathic interaction analyses of small organic activators binding to antithrombin; GT Gunnarsson and UR Desai (2004) Bioorganic and Medicinal Chemistry 12, 633-640. [pdf]
  21. Roles of N-terminal region residues Lys11, Arg13 and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change; S Schedin-Weiss, UR Desai, SC Bock, ST Olson and I Björk (2004) Biochemistry 43, 675-683. [pdf]
  22. New antithrombin–based anticoagulants; UR Desai (2004) Medicinal Research Reviews 24, 151-181. [pdf]
  23. Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and conformational activation; MA Jairajpuri, A Lu, UR Desai, ST Olson, I Björk, and SC Bock (2003) Journal of Biological Chemistry 278, 15941-15950. [pdf]
  24. Exploring new non-sugar sulfated molecules as activators of antithrombin; GT Gunnarsson and UR Desai (2003) Bioorganic and Medicinal Chemistry Letters 13, 579-583. [pdf]
  25. Cytotoxic cell granule-mediated cell death: Characterization of the macromolecular complex of granzyme B with serglycin; SM Raja, B Wang, M Dantuluri, UR Desai, B Demeler, K Speigel, SS Metkar and CJ Froelich (2002) Journal of Biological Chemistry 277, 49523-49530. [pdf]
  26. Interaction of sulfated flavanoids with antithrombin: Lessons on the design of organic activators; GT Gunnarsson and UR Desai (2002) Journal of Medicinal Chemistry 45, 4460-4470. [pdf]
  27. The importance of lysine 125 for heparin binding and activation of antithrombin; S Schedin-Weiss, UR Desai, SC Bock, PGW Gettins, ST Olson and I Bjö rk (2002) Biochemistry 41, 4779-4788. [pdf]
  28. Designing small, non-sugar activators of antithrombin using hydropathic interaction analyses; GT Gunnarsson and UR Desai (2002) Journal of Medicinal Chemistry 45, 1233-1243. [pdf]
  29. Probing reactive center loop insertion in serpins: A simple method for ovalbumin; UR Desai, J Johns, L Lahaye, and HT Wright (2002) Analytical Biochemistry 302, 81-87. [pdf]
  30. Role of Arg 129 in heparin binding and activation of antithrombin; UR Desai, RS Swanson, SC Bock, I Bjö rk, ST Olson (2000) Journal of Biological Chemistry 275, 18976-18984. [pdf]
  31. Hydropathic interaction analysis of the sequence-specific heparin pentasaccharide binding to antithrombin; UR Desai and GT Gunnar (1999) Medicinal Chemistry Research 9, 643-655. [pdf]
  32. Configurational and conformational analyses of a-methylene-g-butryo steroidal spirolactones; MS Sawant, PJ Nadkarni, UR Desai, R Katoch, SS Korde, and GK Trivedi (1999) Journal of the Chemical Society – Perkin Transactions I 2537-2542. [pdf]
  33. Mechanism of heparin activation of antithrombin: Evidence for an induced-fit model of allosteric activation involving two interaction subsites; UR Desai, M Petitou, I Bjö rk, and ST Olson (1998) Biochemistry 37, 13033-41. [pdf]
  34. Highly stereoselective synthesis of spiro-a-methylene-g-butryo-lactones : the role of a-hydroxy substitution; MS Sawant, R Katoch, GK Trivedi, and UR Desai (1998) Journal of the Chemical Society – Perkin Transactions I 843-846. [pdf] 
  35. Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin; UR Desai, M Petitou, I Bjö rk, and ST Olson (1998) Journal of Biological Chemistry 273,7478-87. [pdf]
  36. Differential behavior of (25R)-5,6-epoxyspirostan-22a-O-3b-ol and (25R)-5,6-epoxyspirostan- 22a-O-3b,4b-diol towards Dowex; SS Korde, MHA Baig, UR Desai, and GK Trivedi (1996) Steroids 61, 290-295. [pdf]
  37. Assessing the structural integrity of a lyophilized protein in organic solvents; UR Desai and AM Klibanov (1995) Journal of American Chemical Society 117, 3940-3945. [pdf]
  38. Strategy for the sequence analysis of heparin; J Liu, UR Desai, X-J Han, T Toida, and RJ Linhardt (1995) Glycobiology 5, 765-774. [pdf]
  39. Conformational analysis of sucrose octasulfate by high resolution nuclear magnetic resonance spectroscopy; UR Desai, IR Vlahov, A Pervin, and RJ Linhardt (1995) Carbohydrate Research 275, 391-401. [pdf]
  40. Molecular weight of heparin using 13C nuclear magnetic resonance spectroscopy; UR Desai and RJ Linhardt (1995) Journal of Pharmaceutical Science 84, 212-215. [pdf]
  41. Measurement of the antithrombin III binding sites in low molecular weight heparins by 13C NMR and by capillary electrophoresis; UR Desai, D Hoppensteadt, J Fareed, and RJ Linhardt (1995) Pharmaceutical Science 1, 349-353. [pdf]
  42. Protein structure in the lyophilized state: A hydrogen isotope exchange/NMR study with bovine pancreatic trypsin inhibitor; UR Desai, JJ Osterhout, and AM Klibanov (1994) Journal of American Chemical Society 116, 9420-9422. [pdf]
  43. Interaction of heparin with antithrombin peptide analogs; JH Bae, UR Desai, A Pervin, EO Caldwell, J Weiler, and RJ Linhardt (1994) Biochemical Journal 301, 121-129. [pdf]
  44. Molecular weight of low molecular weight heparins by 13C nuclear magnetic resonance spectroscopy; UR Desai and RJ Linhardt (1994) Carbohydrate Research 255, 193-212. [pdf]
  45. New approaches for the preparation of hydrophobic heparin derivatives; J Liu, A Pervin, CM Gallo, UR Desai, CLV Gorp, and RJ Linhardt (1994) Journal of Pharmaceutical Sciences 83, 1034-1039. [pdf]
  46. Low molecular weight dermatan sulfate as antithrombotic agent: Structure-activity relationship studies; RJ Linhardt, UR Desai, J Liu, A Pervin, D Hoppensteadt, and J Fareed (1994) Biochemical Pharmacology 47, 1241-1252. [pdf]
  47. Specificity studies on the heparin lyases from Flavobacterium heparinum; UR Desai, HM Wang, and RJ Linhardt (1993) Biochemistry 32, 8140-8145. [pdf]
  48. Substrate specificity of the heparin lyases from Flavobacterium heparinum; UR Desai, HM Wang, and RJ Linhardt (1993) Archives of Biochemistry and Biophysics 306, 461-468. [pdf]
  49. Oligosaccharide composition of heparin and low-molecular-weight-heparins by capillary electrophoresis; UR Desai, HM Wang, SA Ampofo and RJ Linhardt (1993) Analytical Biochemistry 213, 120-127. [pdf]
  50. Heparin and its interaction with antithrombin – III; RJ Linhardt, RE Edens, J Bae, UR Desai, A Pervin, E Caldwell, and JM Weiler (1993) Thrombosis Haemostasis 69, 656. [pdf]
  51. Conformational analysis of A- and B-rings in 2-, 4-, and 6-bromosubstituted steroidal 4-en-3-ones by NMR; R Sridharan, UR Desai, RM Rao and GK Trivedi (1993) Steroids 58, 170-177. [pdf]
  52. Synthesis of 2'-(3a-benzyloxy-24-norcholan-23 yl)-2',4',4'-trimethyl-4',5'-dihydrooxazoline-N-oxyl. A new potential spin probe for biomembranes; S Banerjee, UR Desai and GK Trivedi (1992) Tetrahedron 48, 133-148. [pdf]
  53. An electrophoresis-based assay for glycosyltransferase activity; KB Lee, UR Desai, MM Palcic, O Hindsgaul and RJ Linhardt (1992) Analytical Biochemistry 205, 108-114. [pdf]
  54. Structure elucidation of a novel acidic tetrasaccharide and hexasaccharide derived from a chemically modified heparin: UR Desai, HM Wang, TR Kelly and RJ Linhardt (1992) Carbohydrate Research 241, 249-259. [pdf]
  55. Allylic acetoxylation of D5-steroids. Observation of competing pathway - a 13C NMR study of 5b-bromo steroids; UR Desai, MHA Baig and GK Trivedi (1992) Indian Journal of Chemistry 30B, 1085-1088.
  56. Carbon-13 NMR spectra of 2-functionalized D4-3-keto steroids. Carbon-1 and carbon-19 probes for conformational preference?; UR Desai and GK Trivedi (1992) Indian Journal of Chemistry 30B, 915-919.
  57. Conformational analysis of ring A and total assignment of 19-functionalized 4-en-3-one steroids. Applicability of 2D-NOE as a crucial technique; UR Desai and GK Trivedi (1991) Journal of Organic Chemistry 56, 4625-4631. [pdf]
  58. Conjugation of spirocyclopropane with carbonyl group. Conformational analysis of spiro(cyclopropane-1,2'-steroids); UR Desai and GK Trivedi (1991) Magnetic Resonance in Chemistry 29, 148-151. [pdf]
  59. New steroid haptens for radioimmunoassay. Synthesis of steroids substituted with thioether or ester linkages at the 2a-position; UR Desai and GK Trivedi (1991) Steroids 56, 185-188. [pdf]
  60. On the protection of 3a-hydroxy group of A/B cis steroids; S Mukhopadhayay, UR Desai and GK Trivedi (1991) Synthetic Communications 21, 757-770. [pdf]
  61. A high yielding synthesis of (25R)-spiro(cyclopropane-1,2'-(19-nor-spirost-4-en-22a-O)-3-one; UR Desai and GK Trivedi (1991) Indian Journal of Chemistry 30B, 635-638. [pdf]
  62. New steroid haptens for radioimmunoassay Part II. Synthesis of thioether bridged haptens for testosterone; UR Desai, MS Sawant and GK Trivedi (1990) Synthetic Communications 20, 2423-2438. [pdf]
  63. Reductive alkylations of nitrochromenes. Synthesis of spiro(N-hydroxy lactams); S Subramaniam, UR Desai and GK Trivedi (1990) Synthetic Communications 20, 1733-1742. [pdf]
  64. A simple, high-yielding synthesis of spiro(cyclopropane-1,2'-steroids); UR Desai and GK Trivedi (1990) Liebigs Annalen der Chemie 711-712. [pdf]

    65. Abstracts
  65. "Role of Hydrophobic Amino Acids in Heparin Binding and Conformational Activation of Antithrombin III"  Mohamad A Jairajpuri, Aiqin Lu, Umesh Desai, Steven T Olson, Ingemar Bjork, Susan C Bock (2003) www.abstractsonline.com/viewer/viewSession.asp?  session APS.13.2 Abstract #141/B141 (pdf)
  66. "The design of new non-sugar small antithrombin activators based on a natural trisaccharide pharmacophore" Gunnarsson GT and Desai UR (2002) Abstract of Papers of 28th National Medicinal Chemistry Symposium, San Diego, CA, p. 135.
  67. (-)-Epicatechin sulfate: A non-sugar, small, synthetic activator of antithrombin; Desai UR and Gunnarsson GT (2001) Circulation 104, supplement II, II-96.
  68. Computerized molecular design of heparin pentasaccharide mimics; Gunnarsson GT and Desai UR (2000) Virginia Journal of Science 51, 107.
  69. Interactive WWW-based 3D molecular visualization for classroom teaching of cardiac glycosides and anticoagulants Desai UR (2000) American Journal of Pharmaceutical Education 64, 86S.
  70. An interactive WWW-based method for a course emphasizing documentation and evaluation of OTC analytical devices; Desai UR, HT Karnes, and WH Soine (2000) American Journal of Pharmaceutical Education 64, 86S.
  71. Role of individual saccharide residues of the heparin pentasaccharide in activation of the serpin, antithrombin; Desai UR, Petitou M, Bjö rk I, and Olson ST (1997) FASEB Journal 11, 3183 Suppl. S.
  72. Approach for sequencing the glycosaminoglycan chains of proteoglycans; Liu J, Desai UR, Linhardt RJ (1993) Abstracts of Papers of the American Chemical Society 206: 16-Carb, Part 1.
  73. Polysaccharide–protein interaction – Study of heparin binding to antithrombin III using a synthetic peptide model; Bae JH, Desai UR, Pervin A, Caldwell E, Weiler JM, Linhardt RJ (1993) Abstracts of Papers of the American Chemical Society 206: 14-Carb Part 1.

    74. Book Chapters
  74. Antithrombin activation and designing novel heparin mimics; UR Desai (2005) In Chemistry and Biology of Heparin and Heparan Sulfate (Eds. HG Garg, RJ Linhardt and CA Hales), Elsevier, NY, pp. 483-512. [pdf]
  75. Cardiovascular agents; UR Desai (2003) In Medicinal Chemistry for Nurse Anesthesia Students (Eds. Drs. Lemont B. Kier and Cynthia Schiek), Association of Nurse Anesthetists. [pdf]
  76. Capillary electrophoresis of sulfated molecules; M Dantuluri and UR Desai (2003) Recent Research Developments in Analytical Biochemistry 3, 169-189. [pdf]

    77. Patents and Invention Disclosures
  77. Design and synthesis of sulfated bis-cyclic agents; UR Desai and GT Gunnarsson (September 2002) VCU Invention # 02-52. Patent application submitted.
  78. Polyacrylic Acids as anti-clotting agents: UR Desai and BH Monien (May 2004) VCU Invention # 04-32.
  79. Synthesis of lignin sulfate. UR Desai, A Raghuraman and JN Thakkar (December 2004) VCU Invention No. 04-90.
  80. Cinnamic Acid-Based Oligomers as Anti-Clotting Agents. UR Desai (February 2006) VCU Invention No. 06-09.
  81. Comprehensive Computational Modeling of the Coagulation-Fibrinolysis-Inflammatory/Immune Systems. UR Desai, LB Kier, C.-K.Cheng, K Ward, and N Menke (October 2006) VCU Invention No. 06-67.
  82. A Method for Fingerprinting Heparin and Low Molecular Weight Heparins. UR Desai and JT King; VCU Invention _________ (January 2008).

 

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Revised: January 24, 2008
Questions or Comments : Dr. Umesh R. Desai