Selected Publications
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Puccio T, Kunka KS, Zhu B, Xu P, Kitten T.
Manganese Depletion Leads to Multisystem
Changes in the Transcriptome of the
Opportunistic Pathogen Streptococcus
sanguinis. Front Microbiol. 2020 Nov
5;11:592615. doi: 10.3389/fmicb.2020.592615.
eCollection 2020. PMID: 33250881
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Zhu B, Green SP, Ge X, Puccio T, Nadhem H,
Ge H, Bao L, Kitten T, Xu P.
Genome-wide identification of Streptococcus
sanguinis fitness genes in human serum and
discovery of potential selective drug
targets. Mol Microbiol. 2020 Oct 20.
doi: 10.1111/mmi.14629. Online ahead of
print. PMID: 33084151 .
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Kong X, Zhu B, Stone VN, Ge X, El-Rami FE,
Donghai H, Xu P. ePath:
an online database towards comprehensive
essential gene annotation for prokaryotes. Sci
Rep. 2019 Sep 10;9(1):12949. doi:
10.1038/s41598-019-49098-w. PubMed PMID:
31506471; PubMed Central PMCID: PMC6737131.
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Serrano MG, Parikh HI, Brooks JP, Edwards
DJ, Arodz TJ, Edupuganti L, Huang B, Girerd
PH, Bokhari YA, Bradley SP, Brooks JL,
Dickinson MR, Drake JI, Duckworth RA 3rd,
Fong SS, Glascock AL, Jean S, Jimenez NR,
Khoury J, Koparde VN, Lara AM, Lee V,
Matveyev AV, Milton SH, Mistry SD, Rozycki
SK, Sheth NU, Smirnova E, Vivadelli SC,
Wijesooriya NR, Xu J, Xu P, Chaffin DO,
Sexton AL, Gravett MG, Rubens CE,
Hendricks-Muņoz KD, Jefferson KK, Strauss JF
3rd, Fettweis JM, Buck GA. Racioethnic
diversity in the dynamics of the vaginal
microbiome during pregnancy. Nat
Med. 2019 Jun;25(6):1001-1011. doi:
10.1038/s41591-019-0465-8. Epub 2019 May
29. PubMed PMID: 31142850; PubMed Central
PMCID: PMC6746180.
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Zhu B, Macleod LC, Newsome E, Liu J, Xu P. Aggregatibacter
actinomycetemcomitans mediates protection of
Porphyromonas gingivalis from Streptococcus
sanguinis hydrogen peroxide production in
multi-species biofilms. Sci Rep. 2019
Mar 20;9(1):4944. doi:
10.1038/s41598-019-41467-9. PubMed PMID:
30894650; PubMed Central PMCID: PMC6426879.
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Zhu B, Macleod LC, Kitten T, Xu P. Streptococcus
sanguinis biofilm formation & interaction
with oral pathogens. Future
Microbiol. 2018 Jun 1;13:915-932. doi:
10.2217/fmb-2018-0043. Epub 2018 Jun
8. Review. PubMed PMID: 29882414; PubMed
Central PMCID: PMC6060398.
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Zhu B, Song L, Kong X, Macleod LC, Xu P. A
Novel Regulator Modulates Glucan Production,
Cell Aggregation and Biofilm Formation
in Streptococcus sanguinis SK36. Front
Microbiol. 2018;9:1154. doi:
10.3389/fmicb.2018.01154. eCollection
2018. PubMed PMID: 29896189; PubMed Central
PMCID: PMC5987052.
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El-Rami F, Kong X, Parikh H, Zhu B, Stone V,
Kitten T, Xu P. Analysis
of essential gene dynamics under antibiotic
stress in Streptococcus sanguinis. Microbiology. 2018
Feb;164(2):173-185. doi:
10.1099/mic.0.000595. PubMed PMID: 29393020;
PubMed Central PMCID: PMC5882076.
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Zhu B, Ge X, Stone V, Kong X, El-Rami F, Liu
Y, Kitten T, Xu P. ciaR
impacts biofilm formation by regulating an
arginine biosynthesis pathway in
Streptococcus sanguinis SK36. Sci
Rep. 2017 Dec 7;7(1):17183. doi:
10.1038/s41598-017-17383-1. PubMed PMID:
29215019; PubMed Central PMCID: PMC5719415.
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Aynapudi J, El-Rami F, Ge X, Stone V, Zhu B,
Kitten T, Xu P. Involvement
of signal peptidase I in Streptococcus
sanguinis biofilm formation. Microbiology. 2017
Sep;163(9):1306-1318. doi:
10.1099/mic.0.000516. Epub 2017 Sep
4. PubMed PMID: 28869408; PubMed Central
PMCID: PMC5817204.
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Stone VN, Xu P. Targeted
antimicrobial therapy in the microbiome
era. Mol Oral Microbiol. 2017
Dec;32(6):446-454. doi:
10.1111/omi.12190. Epub 2017 Aug
1. Review. PubMed PMID: 28609586; PubMed
Central PMCID: PMC5697594.
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El-Rami F, Nelson K, Xu P. Proteomic
Approach for Extracting Cytoplasmic Proteins
from Streptococcus sanguinis using Mass
Spectrometry. J Mol Biol
Res. 2017;7(1):50-57. doi:
10.5539/jmbr.v7n1p50. PubMed PMID: 29152022;
PubMed Central PMCID: PMC5693382.
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Liu J, Stone VN, Ge X, Tang M, Elrami F, Xu
P. TetR
Family Regulator brpT Modulates Biofilm
Formation in Streptococcus sanguinis. PLoS
One. 2017;12(1):e0169301. doi:
10.1371/journal.pone.0169301. eCollection
2017. PubMed PMID: 28046010; PubMed Central
PMCID: PMC5207742.
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Ge X, Shi X, Shi L, Liu J, Stone V, Kong F,
Kitten T, Xu P*.
Involvement of NADH Oxidase in Biofilm
Formation in Streptococcus sanguinis.
PLoS One. 2016 Mar 7;11(3):e0151142.
doi: 10.1371/journal.pone.0151142.
eCollection 2016 PMID: 26950587(PDF).
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Ge X, Yu Y, Zhang M, Chen L, Chen W, Elrami
F, Kong F, Kitten T, Xu P*.
Involvement of NADH Oxidase in Competition
and Endocarditis Virulence in Streptococcus
sanguinis. Infect Immun. 2016
Feb 29. pii: IAI.01203-15.
PMID: 26930704
(PDF)
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Stone VN, Parikh HI, El-Rami F, Ge X, Chen
W, Zhang Y, Kellogg GE, Xu P*.
Identification of Small-Molecule Inhibitors
against Meso-2, 6-Diaminopimelate
Dehydrogenase from Porphyromonas gingivalis.
PLoS One. 2015 Nov
6;10(11):e0141126. doi:
10.1371/journal.pone.0141126. eCollection
2015 PMID: 26544875(PDF)
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Crump KE, Bainbridge B, Brusko S, Turner LS,
Ge X, Stone V, Xu P, Kitten T*. The
Relationship of the Lipoprotein SsaB,
Manganese, and Superoxide Dismutase in
Streptococcus sanguinis Virulence for
Endocarditis. Mol Microbiol.
2014 Jun;92(6):1243-59. doi: 10.1111/mmi.12625. PMID:
24750294
(PDF)
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Xu P*, Gunsolley J. Application of
metagenomics in understanding oral health
and disease. Virulence. 2014
Mar 18;5(3). Review. PMID: 24642489
(PDF)
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Rhodes DV, Crump KE, Makhlynets O, Snyder M,
Ge X, Xu P, Stubbe J, Kitten T*. Genetic
Characterization and Role in Virulence of
the Ribonucleotide Reductases of
Streptococcus sanguinis. J Biol Chem.
2014 Feb 28;289(9):6273-87. doi:
10.1074/jbc.M113.533620. Epub 2013 Dec 31. PMID: 24381171
(PDF)
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Evans K, Stone V, Chen L, Ge X, Xu P*.
Systematic Study Of Gene Functions For Chain
Length In Streptococcus sanguinis.
Microbiology. 2014
Feb;160(Pt2):307-15.doi:
10.1099/mic.0.071688-0. PMID: 24295823
(PDF)
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Ge X, Rodriguez R, Trinh M, Gunsolley J, Xu
P.* Oral microbiome of deep and shallow
dental pockets in chronic periodontitis.
PLoS One. 2013 Jun 6;8(6):e65520. doi:
10.1371/journal.pone.0065520.(article)
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Trihn M, Ge X, Dobson A, Kitten T, Munro CL,
Xu P*. Two-Component System Response
Regulators Involved in Virulence of
Streptococcus pneumoniae TIGR4 in Infective
Endocarditis. PLoS One. 2013;8(1):e54320. doi: 10.1371/journal.pone.0054320. (article)
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Chen L, Ge X, Wang X, Patel JR, Xu P*. SpxA1
Involved in Hydrogen Peroxide Production,
Stress Tolerance and Endocarditis Virulence
in Streptococcus sanguinis. PLoS One.
2012;7(6):e40034. Epub 2012 Jun 29.(article)
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Xu P*, Ge X, Chen L, Wang X, Dou Y, Xu JZ,
Patel JR, Stone V, Trinh M, Evans K, Kitten
T, Bonchev D, Buck GA. (2011) Genome-wide
essential gene identification in
Streptococcus sanguinis. Scientific
Reports Volume: 1, Article number:
125 DOI: doi:10.1038/srep00125. (article)
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Manque PA, Probst C, Pereira MC, Rampazzo
RC, Ozaki LS, Pavoni DP, Silva Neto DT,
Carvalho MR, Xu P, Serrano MG, Alves
JM, Meirelles Mde N, Goldenberg S, Krieger
MA, Buck GA*. (2011) Trypanosoma cruzi
infection induces a global host cell
response in cardiomyocytes. Infect
Immun. 2011 May;79(5):1855-62. Epub
2011 Feb 22. (PDF)
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Chen L, Ge X, Dou Y, Wang X, Patel JR, Xu
P*.(2010) Identification of hydrogen
peroxide production related genes in
Streptococcus sanguinis and their functional
relationship with pyruvate oxidase.
Microbiology. 2010 Sep 16.
(PDF)
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Ge X, Kitten T, Munro CL, Conrad DH, Xu P*
(2010) Pooled Protein Immunization for
Identification of Cell Surface Antigens in
Streptococcus sanguinis. PLoS ONE
5(7): e11666.
doi:10.1371/journal.pone.0011666
(PDF)
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Das S, Kanamoto T, Ge X, Xu P, Unoki T,
Munro CL, Kitten T*. Contribution of
lipoproteins and lipoprotein processing to endocarditis virulence in Streptococcus
sanguinis. J Bacteriol. 2009
Jul;191(13):4166-79.
(PDF).
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Ge X, Kitten T, Chen Z, Lee S, Munro CL and
Xu P*. Identification of Streptococcus
sanguinis genes required for biofilm
formation and examination of their role in
endocarditis virulence. Infection &
Immunity, June; 76 (6), 2008.
(PDF).
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Xu P,
Alves JM, Kitten T, Brown A, Chen Z, Ozaki
LS, Manque P, Ge X, Serrano MG, Puiu D,
Hendricks S, Wang Y, Chaplin MD, Akan D,
Paik S, Peterson DL, Macrina FL, Buck GA*.
Genome of the opportunistic pathogen
Streptococcus sanguinis. J Bacteriol.
2007 Apr;189(8):3166-75.
(PDF).
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Xu P,
Widmer G, Wang Y, Ozaki LS, Alves JM,
Serrano MG, Puiu D, Manque P, Akiyoshi D,
Mackey AJ, Pearson WR, Dear PH, Bankier AT,
Peterson DL, Abrahamsen MS, Kapur V, Tzipori
S, Buck GA*. The genome of Cryptosporidium hominis. Nature. 2004 Oct
28;431(7012):1107-12.
(PDF)
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Abrahamsen MS*, Templeton TJ, Enomoto S, Abrahante JE, Zhu G, Lancto
CA, Deng M, Liu C, Widmer G, Tzipori S, Buck
GA, Xu P, Bankier AT, Dear
PH, Konfortov BA, Spriggs HF, Iyer L,
Anantharaman V, Aravind L, Kapur V. Complete
genome sequence of the apicomplexan,
Cryptosporidium parvum. Science.
2004 Apr 16;304(5669):441-5 (PDF)
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