J Comprehensible Results

Home Abstract Introduction
Relative Levels of Myelin Basic Proteins Relative Levels of Myelin-Associated Glycoprotein Relative Levels of MAG-Fyn Interaction Number, Diameter, and G Ratio of Axons
Biphasic Dose Response Curve Importance of MAG
Background Study Design Western Blot Coimmunoprecipitation References

Journal of Comprehensible Results

Sanchez E, Bigbee J, Fobbs W, Robinson S, Sato-Bigbee C (2008)
Opioid Addiction and Pregnancy:Perinatal Exposure to Buprenorphine
Affects Myelination in the Developing Brain.
Glia 56:1010-1027

(Translated by Brenna Kent)

Study Design

  
Pregnant rats were implanted with minipumps that either delivered sterile water, 0.3 mg/kg/day or 1 mg/kg/day of buprenorphine. Then offspring were examined at 12, 19, or 26 days of age. The 0.3 mg/kg/day group is meant to represent therapeutic levels of buprenorphine and the 1 mg/kg/day group is meant to represent abuse or overexposure to buprenorphine. The ages at which the offspring were observed model the rapid myelination that occurs during the first two years of life in humans. Measurements were also taken at different ages to observe how myelin develops.