BNFO 301 
Introduction to Bioinformatics
Topic: Research Project
Spring 2014 

Rationale

OK, this is the main event.

Why 'What is a Gene'? Why origins of replication? Why BioBIKE? ...all of that so that you could be prepared for the analysis of phage genomes, a project that will consume most of the remainder of the semester.

There's too much to learn about genome analysis. There's WAY too much to learn. Never mind you, there's too much for ME to learn, or any other human for that matter. Fortunately, humans have made significant progress despite the fact that no single human is an expert in all areas. The strategy for your research project is similar to the strategy for all large research projects: each person becomes expert in a small slice of the pie and conversent about other people's slices. Each person contributes to the whole, even though the whole is too big for any single person to comprehend.

To facilitate this, you'll be part of a small group with a common interest in a large topic. You'll each have a smaller topic within that focus. Each group will meet with me once a week, but I anticipate you will want to communicate in some way amongst yourselves more frequently than that.

Along the way:

  • You'll develop a bibliography on your specific topic (to gain the sense of expertise). Each member of the group will probably want to share articles you find with other members, for common inspiration.
     
  • You'll present your work first to the world (at least the world of your colleagues).
     
  • You'll also write a report detailing your progress.

Time Line
24 Mar Groups announced: and posted
30 Mar Submit tentative topic: Submit questionnaire
31 Mar - 30 Apr Group meetings: See meeting times
7 Apr E-mail reference list: Create a list of articles useful for your specific topic.
29 Apr E-mail title of presentation: The Symposium schedule needs to be solidified, and that requirs a title from each presenter and an overall title for the group..
1 May Presentations to peers: Present work to each other and offer critiques
5 May Critiques due: Send your wisdom to your peers regarding their presentations
9 May Reports due

General Advice and Examples

    Overview: What and Why Research Proposal?

    Advice: How to find a research topic

    Advice: How to build a bibliography
                 (also see the sample protein-centered project, Part I)

    Advice: How to prepare a presentation on your work

    Advice: Logistics of the Symposium, and what you need to do

    Advice: How to critique others' presentations

    Advice: How to write a report on your project

Groups (click here for group assignments)

Each group is defined by a core focus, which comes with multiple possibly pertinent articles. Group members may use the articles as inspiration, a starting point to find other pertinent articles, and an aid in defining and subdividing the project. A group is under no obligation to stick to any predetermined agenda, so long as it goes in a direction that is even more interesting than the original. The notes on Repeats, Tandem Repeats, and Pattern Matching provide a brief overview of the major topics, but it is no substitute for reading the articles suggested at each group's web page.

Each person will have an individual project. You may focus on a single bacterial or phage genome or compare multiple genomes.

Starting the week of March 31, I will be meeting with each group at a specified time (time and place yet to be solidified, but see your group below). Groups are encouraged to meet outside of this time to exchange insights useful to all. I've used the schedules you sent me prior to the last exam to find common times available to members of the group, listed along with your group.

  1. Tandem repeats and CRISPRs (group member contacts)
    Suggested meeting time: Tuesdays, 10:00 AM, Oliver Hall-Education, Rm 2122
    Additional available meeting times: Tuesdays, 9:00 AM, Tuesdays 5:00 PM?, Sundays 4:30 PM?
     
  2. Short dispersed repeats (group member contacts)
    Suggested meeting time: Tuesdays, 9:00 AM, Oliver Hall-Education, Rm 2122
    Additional available meeting times: Mondays 5:30 PM, Tuesdays 10:00 AM, Wednesdays, 9:00 AM
     
  3. Very short dispersed repeats (group member contacts)
    Suggested meeting time: Mondays, 7:45 PM, Harris Hall Computer Lab
    Additional available meeting times: Tuesdays 5:30 PM, Tuesdays 9:00 AM, Tuesdays 10:00 AM, Sundays 4:30 PM?
     
  4. Clustered repeats and potential regulatory sequences (group member contacts)
    Suggested meeting time: Mondays, 1:00 PM, Harris Hall, Room 3104
    Additional available meeting times: Tuesdays 10:00 AM, Tuesdays 1:00 PM