THE CURRAN-MACINTOSH MODEL

A

B

C

FLUID MOVES

R ---> L

HYPERTONIC FLUID

INJECTED

MEMBRANES: TIGHT LOOSE

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The compartments labeled "A" and "C" are of the
same composition (isotonic).

The analogies with the intestinal epithelium:
Compartment A: Gut lumen
Compartment B: Interstitial Space
Compartment C: Blood
Tight Membrane: Tight junction
Loose Membrane: Basement Membrane
Hypodermic: Sodium-potassium ATPase

pumping sodium from cell to interstitial Space

The holistic explanation (Fidleman & Mikulecky).

In parallel with the classical mechanism (pericellular) is a transcellular mechanism:

Compartment C: Gut lumen

Compartment B: Cell

Compartment A: Blood

Tight Membrane: Basolateral Cell Membrane

Loose Membrane: Apical Cell Membrane

Hypodermic: Sodium-potassium ATPase pumping sodium from cell to interstitial Space