Study Guide II - Labeling and TLC

  1. What about 99mTc?
    1. What are the different states?
    2. Why and how is it reduced?
    3. Name several reducing agents and which one is the most popular?
    4. How is bound technetium compound re-oxidize?
    5. What are the different impurities found in solution of bound technetium?
    6. What is a a ligand exchange (or transchelation / give an example.
    7. What by-product occurs with stannous ion when there is too much tin in solution?
    8. What happens to the compounding process if there is too little stannous ion?
    9. What is the ratio of the reducing agent to the pertechnetate?
    10. Define bifunctional Cheaters. Give an example.
    11. Consider the role of 99Tc and 99mTc ratios and the application when you apply the T1/2.
    12. Identify the three method and the protocols to labeling RBCs.
  2. Related to Hot Lab QC be able to complete the following calculations
    1. Constancy
    2. Accuracy
    3. Geometric Variation
    4. Linearity
    5. CPM to DPM on a well counter
  3. Other parts of the up and coming exam will include:
    1. Identify the different forms of radiopharmaceutical biodistribution.
    2. Identify the properties of pertechnetate and determine why it is an "ideal" radioisotope.
    3. Calculate the amount of pertechnetate available several hours after the initial morning elution.
    4. Know your half-lives, which include but not limited to: 123I, 201Tl, 99Mo, 137Cs, 99mTc, 18F, 68Ge, and 57Co

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11/23