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Drugs That May Affect or Alter Radiopharmaceutical
Distribution in Hepatobiliary Imaging |
| Causative Drug | Appearance on Scintiphotos |
| Alcohol | Delayed or non visualization, decreased emptying of the gallbladder |
Antimuscarinics |
Delayed radiotracer clearance (decreased gallbladder emptying) |
| Atropine | Delayed biliary to bowel transit time |
Bethanecol |
Delayed radiotracer clearance from gallbladder; increased biliary to bowel transit time |
Cholecystokinin |
Stimulates gallbladder contraction to promote emptying |
| Exogenous hormones | Breast uptake |
| Hepatic artery chemoinfusion | Non visualization of the gallbladder |
Meperidine |
Delayed visualization of gastrointestinal tract and gallbladder clearance |
Morphine |
Delayed visualization of gastrointestinal tract and gallbladder clearance |
Nicotinic. acid |
Diminished liver uptake due to hepatotoxicity |
Phenobarbital |
Enhances and accelerates biliary excretion of the radiotracer |
Sincalide |
Stimulates gallbladder contraction to promote emptying |
Total parenteral nutrition |
Inhibits biliary to bowel transit tine: nutrition may lead to non visualization of the gal bladder |
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