74. Sanganwar, Ganesh P.; Sathigari, Sateeshkumar; Babu, R. Jayachandra; Gupta, Ram B.. Simultaneous production and co-mixing of microparticles of nevirapine with excipients by supercritical antisolvent method for dissolution enhancement. European Journal of Pharmaceutical Sciences (2010), 39(1-3), 164-174.
Abstract
Microparticles of a poorly
water-sol. model drug, nevirapine (NEV) were prepd. by supercrit.
antisolvent (SAS) method and simultaneously deposited on the surface of
excipients such as lactose and microcryst. cellulose in a single step
to reduce drug-drug particle aggregation. In the proposed method,
termed supercrit. antisolvent-drug excipient mixing (SAS-DEM), drug
particles were pptd. in supercrit. CO2 vessel contg. excipient
particles in suspended state. Drug/excipient mixts. were
characterized for surface morphol., crystallinity, drug-excipient
physico-chem. interactions, and mol. state of drug. In addn., the
drug content uniformity and dissoln. rate were detd. A highly
ordered NEV-excipient mixt. was produced. The SAS-DEM treatment
was effective in overcoming drug-drug particle aggregation and did not
affect the crystallinity or physico-chem. properties of NEV. The
produced drug/excipient mixt. has a significantly faster dissoln. rate
as compared to SAS drug microparticles alone or when phys. mixed with
the excipients.
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