13. Gupta, Ram B.; Kumar, Rajesh;
Betageri, Guru V. Phase Behavior of
Mixtures Containing Antibiotics. Chloramphenicol
Partitioning.
Abstract
Phase equil. behavior of antibiotics is important in drug design and for optimization of the recovery processes in manufg. Antibiotics are high-cost fine chems., mostly manufd. by fermn. using inexpensive substrates. The major cost of manufg. is involved in the sepn. processes. The aq./org. partitioning behavior of a clin. important antibiotic, chloramphenicol, is measured. The org. phase includes the pure solvents n-hexane, CHCl3, di-Et ether, and EtOAc. In addn., measurements are also made for a mixed org. phase composed of n-hexane and EtOAc. Partitioning increases with the hydrogen bonding tendency of the solvent in the order n-hexane < chloroform < di-Et ether < Et acetate. Based on UNIQUAC and lattice-fluid hydrogen-bonding theories, an activity coeff. model (UNIQUAC-HB) is developed that includes hydrogen-bonding interaction. Single-solvent org.-phase data are correlated with the model, and free energy of hydrogen bonding parameters are obtained. Predictions made for mixed-solvent org.-phase systems agree well with the exptl. data without using any adjustable parameter.
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