Gigi Meyer
Modeling the Effects of Polyunsaturated Fatty Acids on the Inflammatory Response in Crohn’s Disease
Abstract
Abstract: Several murine studies have shown an anti-inflammatory
response when specific polyunsaturated fatty acids are included
regularly in the diet. It is believed that the fatty acids serve as a
specific ligand that activates the Peroxisome Proliferator Activated
Receptor (PPAR) which is located on several types of cells active in
the inflammatory response to modify the process. An ordinary differential equation
model of inflammation specific to Crohn’s disease with dietary interventions and PPAR
receptor dynamics is being developed to describe this process, and
preliminary results will be discussed.
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