Statistical Methods in Systems Biology
BIOS 691-803; Winter/Spring 2008
Instructor: Dr. Mark Reimers, VCU
Outline
Comparison of pathway configurations between control and disease/treatment groups
Outlier analysis to identify causal processes in genetic disease
Inter-individual variation as a measure of pathway dysfunction
Multivariate analysis of epigenomic data
Integration of epigenomic and transcription data
Enrichment analysis of motifs in promoters of regulated genes
Combining a priori thermodynamic modeling and expression data
Use of ChIP array and expression array data to infer transcription factor binding sites
Expression as a phenotype
Highly parallel linkage peak analysis
Network analysis using Gene Ontology categories
Combining promoter and genetic analysis
Class Presentations