BNFO 491 
Molecular Biology Through Discovery
Questionnaire on notes: Crick (1958) and Crick et al (1961) - Nature of the Genetic Code
and Jones and Nirenberg (1962) - Breaking the Code
(please press SUBMIT button when finished)
WARNING! Please don't use double quoatation marks in your answers.
(The questionnaire program dies when it encounters them!)
Fall 2012 


I. Basic Information

A. Your name 
II. Old business - Critique of sample summaries

What specific suggestions do you have for the two summaries accessible from the October 16 calendar entry?
     

III. Old business - Crick (1958) On Protein Synthesis

A. How far have you gotten in Crick (1958) (and its companion)?
     

Consider how comfortable you are with the following topics regarding protein synthesis:

B. The simplifying and explanatory power of the sequence hypothesis

C. How nature of ribosomes as they are understood today

D. The 1950's view of the role of ribosomes in protein synthesis

E. The adaptor hypothesis and the need for something like tRNA

F. Different kinds of genetic codes: (non)overlapping, different lengths, degeneracy

G. Crick's comma-less code
     

Choose up to five study questions that you would most like discussed in class concerning Crick (1958):

SQ1  SQ2 SQ3 SQ4 SQ5 SQ6 SQ7  SQ8  SQ9 
SQ10 SQ11 SQ12 SQ13  SQ14 SQ15 SQ16 SQ17 
SQ18  SQ19 SQ20 SQ21 SQ22 SQ23 SQ24 SQ25 
SQ26 SQ27 SQ28 SQ29 SQ30 SQ31 
IV. Old business: Crick et al (1961) General Nature of the Genetic Code

A. How far have you gotten in Crick et al (1961) (and its companion)? The simulation?
     

Consider how comfortable you are with the following topics regarding Crick et al (1961):

B. The prediction of the loop code shown in Fig. 2 of the companion

C. Mutagenesis by acridines

D. Recombination between two phages

E. The nature of suppressor mutations as relevant to Crick et al (1961)

F. How to construct new mutant T4 phages

G. What the double and triple mutants say about the genetic code
     

Choose up to five study questions that you would most like discussed in class:

SQ1  SQ2 SQ3 SQ4 SQ5 SQ6 SQ7  SQ8  SQ9 
SQ10 SQ11 SQ12 SQ13  SQ14 SQ15 SQ16 SQ17 
SQ18  SQ19 SQ20 SQ21 SQ22 SQ23 SQ24 
V. Jones & Nirenberg (1962) Survey of RNA codewords

A. How far have you gotten in JOnes & Nirenberg (1962) (and its companion)? The Alien Genetic Code?
     

Consider how comfortable you are with the following topics regarding these matters:

B. The overall goal of the work by Nirenberg and others

C. The specific focus of Jones & Nirenberg (1961)

D. The nature of the experiment

E. The nature of RNA produced by polynucleotide phosphorylase

F. Theoretical expectations of experiment J108, Table 3

G. Interpretation of Table 3

H. How to deduce the alien genetic code
     

Choose up to four study questions that you would most like discussed in class:

SQ1  SQ2 SQ3 SQ4 SQ5 SQ6 SQ7  SQ8  SQ9 
SQ10 SQ11 SQ12 SQ13  SQ14 SQ15 SQ16 
VI. Miscellaneous

Any other comments, questions, suggestions, or concerns you may have?

Thanks!

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