BNFO 491 
Molecular Biology Through Discovery
Questionnaire on article: Perutz et al (1965)
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WARNING! Please don't use double quoatation marks in your answers.
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Fall 2012 


I. Basic Information

A. Your name 
II. Direction of course
The number of questionnaires returned each class continues to be small. Attendance has dwindled. Few people have completed what I believe may be the most important assignment of the course thus far -- the gene annotation.

One interpretation is that the material of the course is so straightforward that you're confident you've already mastered it. My perception is that this is not true (or if true, then your confidence is misplaced).

Another is that the material is of insufficient interest to warrent your attention.

A third is that you are suffering from sensory overload and are locking down.

Whatever the case, I feel the need to hear your thoughts on your progress in the course and what direction we should take. To help focus your thoughts, I've updated the calendar, with completed September and nearly completed October, including a description of the second exam.

A. Please consider the following questions and then tell me your thoughts on the direction of this course:

  1. Do you understand the goals of the course? Are they important to you?
  2. Most people are way behind the schedule of activities for this course. What should be done about that?
  3. What would make the class useful to you, sufficiently that it would be worth your time?
  4. What other thoughts do you have concerning the direction of the course and your progress within it?
     

B. Are you interested in time to meet with the TA, either individually or as part of a group? Are you available during the two scheduled TA sesssions (Tue 5:30-6:30pm; Thu 5:15-6:15pm)? If not, then what would be better times for you?
     

III. Annotation of a Gene (old business)
(No need to respond to this section if you've done so in an earlier questionnaire and nothing's changed)

A. How far have you gotten in annotating a gene?
     

Consider how comfortable you are with the following topics (in the notes Annotation of a Gene):

B. If you have completed the annotation, how do you feel about it? Are you confident that your article and summary of an experiment adequately justifies the main annotation of the gene?

C. If you have not completed the annotation, what stands in your way?

D. In either case, how comfortable do you feel regarding the notion of what constitutes justification as opposed to a mere claim?
     

IV. Sanger and Tuppy (1951) (more old business)
(No need to respond to this section if you've done so in an earlier questionnaire and nothing's changed)

A. How far have you gotten in Problem Set 4, Problem #1 (determination of the sequence of insulin)?
     

B. We need to move on, but anything regarding this article and Problem Set 4, Problem #1 remains an obstacle for you?
     

V. Perutz et al (1965)
Consider how comfortable you are with the following topics (as defined by the companion to Perutz et al):

A. The different ways protein structures are presented graphically

B. The basis for the formation of alpha helices

C. The role of hydrophobicity in determining the three dimensional structure of proteins

D. How to Protein Explorer

E. The significance of invariant amino acids in the structure of globin

F. The significance of prolines in the structure of globin

With this in mind, how could class time best be spent to meet your needs?
     

Choose up to five study questions, those that you have already struggled with, that you would most like discussed in class:

SQ1  SQ2 SQ3 SQ4 SQ5 SQ6 SQ7  SQ8  SQ9 
SQ10 SQ11 SQ12 SQ13 SQ14 SQ15 SQ16 SQ17 
SQ18 SQ19  SQ20 SQ21 SQ22 SQ23 SQ24 SQ25 
SQ26 SQ27 SQ28 SQ29 SQ30 SQ31 SQ32 SQ33 
V. Miscellaneous
Any other comments, questions, suggestions, or concerns you may have?

Thanks!

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