BNFO 300 
Molecular Biology Through Discovery
Semester Projects
Fall 2018 

Below is a tentative list of semester projects to be presented December 11 - 14 2018. Semester projects come in two types:
  • Research proposal (P): Each proposal justifies and describes a single experiment aimed at addressing a small part of a large and significant questionof how something works at the molecular level. The aim is depth, getting to the bottom of an experiment to the extent that the presenter can explain the principles behind all techniques used and how the techniques contribute to the experiment. Each proposer has been mentored by a member of the VCU research community. Here's an example.
     
  • Translation of a research article (T): The goal is to make a research article comprehensible to a general audience, not in the matter of a news article that focuses on the results and their significance. Instead, translations focus on the workings of the experiments (at least one of which is molecular in nature) -- not what we know but how we know it. Here's an example.

You can see general advice that was given regarding how to write a research proposal and how to give a presentation. Each presentation will be about 7-8 minutes, with the same time for questions.

PROPOSER MENTORTYPETITLE
Wassal AlhammadYousef Alhashem
T
KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells
Leila AlickovicGlen Kellogg
P
Accounting for side-chain flexibility in protein-ligand docking: 3D Interaction Homology as an approach of quantifying side-chain flexibility of tyrosine rotamers
Sharoon ArshadBecca Martin
P
Furin deletion in B cells alters ADAM10 prodomain processing and the downstream effects on allergic asthma
Emaan ChaudryKeith Baker
T
A HIF-independent mediator of transcriptional responses to oxygen by deprivation in Caenorhabditis elegans
Ramtin DeljoueiRita Shiang
P
Functional analysis of CMYA5 via CRISPR/Cas9 knockout
Daanish Fiaz Mitra Menon
T
Antisenescence effect of mouse embryonic stem cell conditioned medium through a PDGF/FGF pathway
Hunter FreemanJennifer Koblinski
P
Is the KLF4 gene or heparanase a more productive punitive target in the gene silencing of breast to brain metastasis?
Casey Harless
P
Detection of endophytic Actinomycete type I PKS/Afs hybrid from Annonaceae
Dalton HueyMike Miles
P
Determining the neuron type specificity of a potential mechanism for alcohol addiction
Nasita IslamJanina Lewis
T
Synthesis and antimicrobial evaluation of amixicile-based inhibitors of the pyruvate-ferredoxin oxidoreductases of anaerobic bacteria and epsilonproteobacteria
Krishna KaramsettyPraveen Bhoopathi
T
mda-7/IL-24 induces cell death in neuroblastoma through a novel mechanism involving AIF and ATM
Brenna KentCarmen Sato-Bigbee
T
Opioid addiction and pregnancy: Perinatal exposure to buprenorphine affects myelination in the developing brain
Farhana KhanPeter Uetz
T
The protein interactome of Streptococcus pneumoniae and bacterial meta-interactomes Improve function predictions
Amrita KondetiWenheng Zhang
P
The functional diversity of CYC2 transcriptional factors during the evolution of Schizanthus
Kethan MahavadiTomasz Kordula
P
Role of cIAP2 in activation of microglia
Mario Melchor-GuerraMike McVoy
P
Targeted mutagenesis of guinea pig cytomegalovirus using CRISPR/Cas9-mediated gene editing
Sarah OtihBill Barton
P
Tie1 and Tie2 dimerization and the possible inhibition of angiogenesis in tumor endothelial cells
Nupur PandyaMartin Safo
P
Development of potential agents for the treatment of sickle cell anemia
Karun RajeshPeter Uetz
T
The protein Interactome of Streptococcus pneumoniae and bacterial meta-interactomes improve function predictions
Jake RodriguezBalaji Nagarajan
P
Understanding the mechanism of chemokine CXCL13 will help improve immunotherapies
Jeetika SainaniBob Dieglemann
T
Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts
Ahson SaiyedJeff Elhai
P
MutL-induced endonuclease activity in cyanobacteria
Perray Saravanane
T
Human mitochondrial DNA polymerase holoenzyme reconstitution and characterization
Ria ShahMike Miles
T
Ethanol regulation of serum glucocorticoid kinase 1 expression in DBA2/J mouse prefrontal cortex
Owais Shahzada
T
Toxicity levels of HIV drugs on the human mitochondrial DNA
Sohail SyedDerek Prosser
T
FFAT rescues VAPA-mediated inhibition of ER-to-golgi transport and VAPB-mediated ER aggregation
Shravani WadwekarPeter Uetz
T
The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli