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I. Basic Information
A. Your name
II. Old business
- Summary of an experiment described in a research article and Critiques
Clear on
how to write a summary,
how to critique someone else's,
and how to submit them through the
BNFO300 summary blog?
Crick et al (1961) and the triplet code
Drawing, perhaps, on the companion to Crick (1961)
and Problem Set 5, Questions 5 and 6, do you understand how Crick et al's
experiment worked? Any concerns
about mutagenesis by acridines? Recombination between two phages? The nature of suppressor mutations? How to
construct multiply mutant phages? What the double and triple mutants say about the genetic code?
Jones & Nirenberg (1962) and Alien Genetic Code
Drawing, perhaps, on the companion to
Jones & Nirenberg (1962), do you understand Jones & Nirenberg's experiment worked? The nature of RNA produced
by polynucleotide phosphorylase? Interpretation of Table 3? How do deduce an
alien genetic code?
Research proposal?
Progress? Problems?
III. Old Research Proposals
A. Have you found and read through one or more research proposals from previous classes? Which one(s)? Have you compared it/them with advice on
how to write a proposal? Any issues or insights?
IV. Brenner et al (1961)
A. Have you gotten the full text of the article? If so, how far have you gotten in it (and its companion)?
B. Consider how comfortable you are with the following topics regarding these matters:
- The general outline of Pardee, Jacob, and Monod's experiment
- The implications of linear vs exponential production of enzyme in that experiment
- The general outline of Riley and Pardee's experiment and its implications
- The three models considered by Brenner et al
- Density shift experiments and density gradient centrifugation
- Interpretation of Figures 2 - 8 in Brenner et al
- Pulse-chase experiments
V. Miscellaneous
Any other comments, questions, suggestions, or concerns you may have?
(nb. Issues concerning your proposal are always welcome)
Thanks!
REMEMBER TO CLICK SUBMIT!
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