BNFO 300 
Molecular Biology Through Discovery
Questionnaire on: Brenner et al (1961) - The discovery of mRNA
(please press SUBMIT button when finished)
Spring 2016  


I. Basic Information

A. Your name  
II. Old business
  1. Belozersky & Spirin (1957) and the DNA/RNA paradox
    Regarding the story regarding Belozersky & Spirin (1957), any concerns about how to read their tables?
    The relationship between their results and the one-ribosome-one-protein hypothesis?
    The paradoxes posed by the two scenarios?

     
  2. Problem Set 7, Questions 1 and 2
    Any final concerns about Problem Set 7, questions 1 and 2 (reproducing and interpreting the results of Belozersky & Spirin (1957))?

     
  3. Research proposal?
    Progress? Problems?

III. Brenner et al (1961)

A. Have you gotten the full text of the article? If so, how far have you gotten in it (and its companion)?
     

B. Consider how comfortable you are with the following topics regarding these matters:

  • The general outline of Pardee, Jacob, and Monod's experiment
     
  • The implications of linear vs exponential production of enzyme in that experiment
     
  • The general outline of Riley and Pardee's experiment and its implications
     
  • The three models considered by Brenner et al
     
  • Density shift experiments and density gradient centrifugation
     
  • Interpretation of Figures 2 - 8 in Brenner et al
     
  • Pulse-chase experiments
     
         
IV. Miscellaneous
Any other comments, questions, suggestions, or concerns you may have?
(nb. Issues concerning your proposal are always welcome)

Thanks!

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