BNFO 300 
Molecular Biology Through Discovery
Questionnaire on notes: Hemoglobin and Perutz et al (1965) (Part 2)
(please press SUBMIT button when finished)
Spring 2016  


I. Basic Information

A. Your name 
II. Old business (no need to repeat anything you've said in a previous questionnaire)

A. Sanger & Tuppy (1953)
     Anything further you'd like to discuss regarding the article Sanger & Tuppy (1953) and its companion?
     Are you making progress recreating their analysis, i.e. completing Problem Set 2, Problem 1, as a community?
    

B. Perutz et al (1965) (Sections I and II)
     Anything further you'd like to discuss regarding the overall questions addressed by the article Perutz et al (1965)?
        (see also its companion)?
     Do you understand the connection between Fig. 1 and Table 2?
    

C. Hemoglobin tutorial
     Anything further you'd like to discuss regarding the tutorial on Hemoglobin Structure?
        (see also the companion, Section III)
     Were you able to run the tutorial? (if not, did you try the suggested fixes?)
     Do you understand the different graphical representations of protein?
     The basis for alpha helix formation? How hydrophobicity contributes to globin structure?
    

III. Perutz et al (1965) (Sections IV through VI)
A. Were you able to run Protein Explorer? (If not, did you try the suggested fixes?)
    If you still can't run the program, please describe what you did and what happened:
   

Consider how comfortable you are with the following topics (as defined by the companion to Perutz et al):

B. Were you able to bring whale myoglobin into Protein Explorer?

C. The significance of invariant amino acids in the structure of globin

D. The significance of prolines in the structure of globin

E. The role of hydrophobicity in the formation of hemoglobin

F. Study questions 16 through 32

What specific problems have you encountered in considering these issues?
    What have you tried to resolve these problems?
Do you have any other questions concerning the material in the notes?

IV. Problem Set 2 (Problem 2 and beyond)
Any issues concerning these problems?
   
V. Miscellaneous
Any other comments, questions, suggestions, or concerns you may have?

Thanks!

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