BNFO 300 
Molecular Biology Through Discovery
Questionnaire on: Brenner et al (1961) - The discovery of mRNA
(please press SUBMIT button when finished)
Fall 2014  


I. Basic Information

A. Your name 
II. Old business
(no need to repeat anything you've said in a previous questionnaire)
  1. Belozersky & Spirin (1957) and the DNA/RNA paradox
    Regarding the story regarding Belozersky & Spirin (1957), any concerns about how to read their tables?
    The relationship between their results and the one-ribosome-one-protein hypothesis?
    The paradoxes posed by the two scenarios?

     
  2. Problem Set 8 - Genetic Code
    Any final concerns about Problem Set 8, e.g. how to use the Crick et al (1961) simulations and how to deduce the alien genetic code?

     
  3. Research proposal?
    Progress? Problems?

III. Brenner et al (1961)

A. Have you gotten the full text of the article? If so, how far have you gotten in it (and its companion)?
     

B. Consider how comfortable you are with the following topics regarding these matters:

  • The general outline of Pardee, Jacob, and Monod's experiment
     
  • The implications of linear vs exponential production of enzyme in that experiment
     
  • The general outline of Riley and Pardee's experiment and its implications
     
  • The three models considered by Brenner et al
     
  • Density shift experiments and density gradient centrifugation
     
  • Interpretation of Figures 2 - 8 in Brenner et al
     
  • Pulse-chase experiments
     
         

C. Choose up to five study questions that you would most like discussed in class and explain why.
     

IV. Miscellaneous

Any other comments, questions, suggestions, or concerns you may have?

Thanks!

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