BNFO 300 
Molecular Biology Through Discovery
Questionnaire on: DNA Structure
(please press SUBMIT button when finished)
Fall 2013 


I. Basic Information

A. Your name 
II. Old Business

(No need to respond to any section if you've done so in an earlier questionnaire and nothing's changed)

A. Research Proposal
The target date for finding a mentor is Friday, September 20, a few days away. After that you'll be doing things that call for input from your mentor (e.g. a bibliography). How far are you along in finding a mentor for your research proposal? Need any help? Feel free to send me for suggestions a proposed e-mail to a candidate faculty mentor.
     

B. Problem Set 4 (Protein Mutation)

Any final concerns about this problem set?
     
III. Old Business: Perutz et al (1965)

(No need to respond to any section if you've done so in an earlier questionnaire and nothing's changed)

A. Have you found the Perutz article?  

B. How far have you gotten in the companion to that article? Refer, perhaps, to the last study question you addressed (e.g. SQ12).  

C. How far have you gotten in Hemoglobin Structure? Refer, perhaps, to the last section and view you completed (e.g. 4, View 7).  

Consider how comfortable you are with the following topics (as defined by the companion to Sanger and Tuppy):

D. The different ways protein structures are presented graphically

E. The basis for the formation of alpha helices

F. The role of hydrophobicity in determining the three dimensional structure of proteins

G. How to Protein Explorer

H. The significance of invariant amino acids in the structure of globin

I. The significance of prolines in the structure of globin

With this in mind, how could class time best be spent to meet your needs?
     

Choose up to five study questions, those that you have already struggled with, that you would most like discussed in class:

SQ1  SQ2 SQ3 SQ4 SQ5 SQ6 SQ7  SQ8  SQ9 
SQ10 SQ11 SQ12 SQ13 SQ14 SQ15 SQ16 SQ17 
SQ18 SQ19  SQ20 SQ21 SQ22 SQ23 SQ24 SQ25 
SQ26 SQ27 SQ28 SQ29 SQ30 SQ31 SQ32 SQ33 
IV. DNA Structure

A. How far have you gotten in DNA Structure?
     

Consider how comfortable you are with the following topics (in the notes DNA Structure):

B. The tetranucleotide hypothesis and why if true it would make it impossible for DNA to be the genetic material

C. The Chargaff rules and how they were found

D. How the double slit experiment works

E. How the helical structure of DNA and internucleotide distances can be discerned from Franklin and Gosling's x-ray photograph

F. The biological significance of Watson and Crick's model and how they arrived at it (model building)
     

Choose up to three study questions related to DNA structure that you would most like discussed in class:

SQ1  SQ2  SQ3  SQ4  SQ5  SQ6  SQ7  SQ8  SQ9 
SQ10  SQ11  SQ12  SQ13 
Consider how comfortable you are with the following topics related to DNA directionality and palindromes:

G. The importance of thinking about DNA sequences in terms of 5'-to-3'

H. The nature of a DNA palindrome

I. The biological roles for palindromic sequences
     

Choose up to two study questions that you would most like discussed in class:

SQ14  SQ15  SQ16  SQ17  SQ18  SQ19  SQ20
V. Miscellaneous

Any other comments, questions, suggestions, or concerns you may have?

Thanks!

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