Angela Reynolds
Associate Professor
Department of Mathematics and Applied Mathematics
- 1. Sarah B. Minucci, Rebecca L. Heise, F. J. Kamga Gninzeko, Michael S. Valentine, Angela M. Reynolds, Mathematical modeling of ventilator-induced lung inflammation, Journal of Theoretical Biology, Volume 526, 7 October 2021, doi.org/10.1016/j.jtbi.2021.110738
- 2. Sarah B. Minucci, Rebecca L. Heise, Angela M. Reynolds, Review of Mathematical Modeling of the Inflammatory Response in Lung Infections and Injuries, Front. Appl. Math. Stat., 26 August 2020 https://doi.org/10.3389/fams.2020.00036
- 3. Heyrim Cho, Allison L. Lewis, Kathleen M. Storey, Rachel Jennings, Blerta Shtylla, Angela M. Reynolds, and Helen M. Byrne, A Framework for Performing Data-Driven Modeling of Tumor Growth with Radiotherapy Treatment, 2021, Peer-reviewed Book Chapter in Using Mathematics to Understand Biological Complexity, Springer’s WBIO series.
- 4. Torres M, Wang J, Yannie PJ, Ghosh S, Segal RA, Reynolds AM. Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization. PLoS Comput Biol. 2019 Jul;15(7):e1007172. doi: 10.1371/journal.pcbi.1007172. eCollection 2019 Jul. PubMed PMID: 31365522; PubMed Central PMCID: PMC6690555.
- 5. Aghasafari P, Heise RL, Reynolds A, Pidaparti RM. Aging Effects on Alveolar Sacs Under Mechanical Ventilation. J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):139-146. doi: 10.1093/gerona/gly097. PubMed PMID: 29746613; PubMed Central PMCID: PMC6333941.
- 6. Valentine MS, Link PA, Herbert JA, Gninzeko FK, Schneck MB, Shankar K, Nkwocha J, Reynolds AM, Heise RL. Inflammation and Monocyte Recruitment due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular Chaperone 4-phenylbutyrate. Cell Mol Bioeng. 2018 Dec;11(6):495-508. doi: 10.1007/s12195-018-0537-8. Epub 2018 Jun 19. PubMed PMID: 30581495; PubMed Central PMCID: PMC6301058.
- 7. Torres M, Trexler ET, Smith-Ryan AE, Reynolds A. A mathematical model of the effects of resistance exercise-induced muscle hypertrophy on body composition. Eur J Appl Physiol. 2018 Feb;118(2):449-460. doi: 10.1007/s00421-017-3787-6. Epub 2017 Dec 18. PubMed PMID: 29256047. Correction to: A mathematical model of the effects of resistance exercise-induced muscle hypertrophy on body composition, September 2018, Volume 118, Issue 9, pp 2035–2037- Minor revision that did not the major findings of this publication. https://doi.org/10.1007/s00421-018-3895-y
- 8. Kim J, Heise RL, Reynolds AM, Pidaparti RM. Quantification of Age-Related Lung Tissue Mechanics under Mechanical Ventilation. Med Sci (Basel). 2017 Sep 29;5(4). doi: 10.3390/medsci5040021. PubMed PMID: 29099037; PubMed Central PMCID: PMC5753650.
- 9. Kim J, Heise RL, Reynolds AM, Pidaparti RM. Aging effects on airflow dynamics and lung function in human bronchioles. PLoS One. 2017;12(8):e0183654. doi: 10.1371/journal.pone.0183654. eCollection 2017. PubMed PMID: 28846719; PubMed Central PMCID: PMC5573216.
- 10. Herbert JA, Valentine MS, Saravanan N, Schneck MB, Pidaparti R, Fowler AA 3rd, Reynolds AM, Heise RL. Conservative fluid management prevents age-associated ventilator induced mortality. Exp Gerontol. 2016 Aug;81:101-9. doi: 10.1016/j.exger.2016.05.005. Epub 2016 May 14. PubMed PMID: 27188767; PubMed Central PMCID: PMC5589142.
- 11. Reynolds AM, Segal RA. Mathematical Modeling of Inflammation . In: Basic Biology and Clinical Aspects of Inflammation. Diegelmann RF, Chalfant CE, editors. Sharjah, U.A.E.: Bentham Science Publishers; 2016. Chapter 15; p.427-450. 427-450p.
- 12. Racheal L. Cooper, Robert F. Diegelmann, Rebecca A. Segal, Angela Reynolds, Modeling the Effects of Systemic Mediators on the Inflammatory Phase of Wound Healing, Volume 367, 21 February 2015, Pages 86–99. DOI: 10.1016/j.jtbi.2014.11.008
- 13. Pidaparti RM, Burnette M, Heise RL, Reynolds A. Analysis for stress environment in the alveolar sac model. J Biomed Sci Eng. 2013 Sep;6(9):901-907. doi: 10.4236/jbise.2013.69110. PubMed PMID: 24932320; PubMed Central PMCID: PMC4057278.
- 14. Reynolds, A., Koombua, K., Ward, K., Pidaparti, R., Cellular Automata Modeling of Pulmonary Inflammation, MCB, vol 9, no 2, pp 141-156, 2012, DOI:10.3970/MCB.2012.009.141
- 15. Segal, R., Diegelmann, R., Ward, K., Reynolds A., A Differential Equation Model of Collagen Accumulation in a Healing Wound, Bulletin of Mathematical Biology, 2012, DOI 10.1007/s11538-012-9751-z.
- 16. John W Cain and Angela M Reynolds, Ordinary and Partial Differential Equations: An Introduction to Dynamical Systems , ISBN#: 978-0-9824062-3-6, 2010, 418 pages, hardback. Free electronic copy available, just e-mail me.
- 17. Reynolds, A., Ermentrout, G. B., Clermont, G, A Mathematical Model of Gas Exchange Under Inflammatory Stress, 2010, J. Theor. Biol., 264, 161-173, doi:10.1016/j.jtbi.2010.01.011
- 18. N.B. Menke, J.W. Cain, A.M. Reynolds, D.M. Chan, R.A. Segal, T.M. Witten, D.G. Bonchev, R.F. Diegelmann, and K.R. Ward, 2009, An In Silico Approach to the Analysis of Acute Wound Healing, Wound Repair and Regeneration. Vol 18, Issue 1, 105-113. doi.org/10.1111/j.1524-475X.2009.00549.x
- 19. Day, J., Rubin, J., Vodovotz, Y., Chow, C.C., Reynolds, A., Clermont, G., 2006. A reduced mathematical model of the acute inflammatory response: II. Capturing scenarios of repeated endotoxin administration. J. Theor. Biol. 242, 37-256. doi: 10.1016/j.jtbi.2006.02.015
- 20. Reynolds, A., Rubin, J., Clermont, G., Day, J., Yodovotz, Y., Ermentrout, G. B., 2006. A reduced mathematical model of the acute inflammatory response: I. Derivation of the model and analysis of anti- inflammation. J. Theor. Biol. 242, 220-236. doi.org/10.1016/j.jtbi.2006.02.016
Research
My research focuses on understanding the role of inflammation in multiple diseases and wound healing using different modeling approaches and computational methods. I have worked on collaborative teams focused on sepsis, Lung health (age-dependent and/or ventilator-induced), Atherosclerosis, and the effects of systemic mediators on wound healing. Additionally, I have collaborated on projects exploring data-driven tumor modeling, sickle cell disease and resistance training.
Graduated PhD students:
Racheal Cooper
Publications