Publications Papers | Book Chapters | PubMed 2011 Ramesh D., Schlosburg JE, Abdullah RA, Kinsey SG, Long JZ, Cravatt BF, Akbarali HI, Sim-Selley LJ, Lichtman AH (2011). Targeting endocannabinoid catabolizing enzymes for the treatment of opioid withdrawal. J Pharmacol Exp Ther. In press Kinsey, S.G., Naidu, P.S., Cravatt, B.F., Dudley, D.T., & Lichtman, A.H. (2011). Fatty acid amide hydrolase blockade produces anti-arthritic affects in the mouse collagen-induced arthritis model. Pharmacol Biochem Behav. In press. Kinsey SG, Nomura DK, O'Neal ST, Long JZ, Mahadevan A, Cravatt BF, Grider JR, Lichtman AH (2011). Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice. J Pharmacol Exp Ther. In press Wise LE, Varvel SA, Selley DE, Wiebelhaus JM, Long KA, Middleton LS, Sim-Selley LJ, Lichtman AH (2011). ∆(9)-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory. Psychopharmacology (Berl). in press Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH (2011). The FAAH Inhibitor PF-3845 Acts in the Nervous System to Reverse Lipopolysaccharide-induced Tactile Allodynia in Mice. Br J Pharmacol. in press Bátkai S, Mukhopadhyay P, Horváth B, Rajesh M, Gao RY, Mahadevan A, Amere M, Battista N, Lichtman AH, Gauson LA, Maccarrone M, Pertwee RG, Pacher P (2011). Δ(8) -Tetrahydrocannabivarin protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress and inflammatory response involving CB(2) receptors. Br J Pharmacol. in press. Lichtman AH, Chapman V. A.(2011). FAAH-fetched approach to treat osteoarthritis pain. Pain. 2011 May;152(5):959-60. Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL (2011). Reversible competitive a-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. J Med Chem. 2011 Apr 28;54(8):2805-22. Epub 2011 Mar 23. Schlosburg JE, O'Neal ST, Conrad DH, Lichtman AH. CB(1) receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action (2011). Psychopharmacology (Berl). 2011 Feb 22. [Epub ahead of print] PubMed PMID: 21340468. Soderstrom K, Poklis JL, Lichtman AH (2011). Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. BMC Neurosci. Jan 6;12(1):3. Kinsey SG, O'Neal ST, Long JZ, Cravatt BF, Lichtman AH (2011). Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. Pharmacol Biochem Behav. 98, 21–27. Kinsey SG, Mahadevan A, Zhao B, Sun H, Naidu PS, Razdan RK, Selley DE, Imad Damaj M, Lichtman AH (2011). The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects. Neuropharmacology. 60, 244-251. Avraham Y, Saidian M, Burston JJ, Mevorach R, Vorobiev L, Magen I, Kunkes E, Borges B, Lichtman AH, Berry EM (2011). Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals. J Nutr Biochem. In press. 2010 Poklis JL, Thompson CC, Long KA, Lichtman AH, Poklis A (2010). Disposition of Cannabichromene, Cannabidiol, and delta-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High-Performance Liquid Chromatography-Tandem Mass Spectrometry. J Anal Toxicol. 2010 Oct 1;34(8):516-520. Lichtman AH, Blankman JL, Cravatt BF (2010). Endocannabinoid overload. Mol Pharmacol. 2010 Dec;78(6):993-5. Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu Q, Lichtman AH, Cravatt BF (2010). Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci. 2010 Sep;13(9):1113-9. Delong GT, Wolf CE, Poklis A, Lichtman AH (2010). Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Delta(9)-tetrahydrocannabinol. Drug Alcohol Depend. 2010 Nov 1;112(1-2):126-33. Kinsey, SG, Long, JZ, Cravatt, BF, & Lichtman, AH (2010). Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms. J Pain. 2010 Dec;11(12):1420-8. Naidu, PS, Kinsey, SG, Guo, TL, Cravatt, BF, & Lichtman, AH. Regulation of Inflammatory Pain by Inhibition of Fatty Acid Amide Hydrolase (FAAH) (2010). J Pharmacol Exp Ther. 2010 Jul;334(1):182-90. Falenski KW, Thorpe AJ, Schlosburg JE, Cravatt BF, Abdullah RA, Smith TH, Selley DE, Lichtman AH, Sim-Selley LJ. FAAH(-/-) Mice Display Differential Tolerance, Dependence, and Cannabinoid Receptor Adaptation After Delta(9)-Tetrahydrocannabinol and Anandamide Administration (2010). Neuropsychopharmacology. 2010 Jul;35(8):1775-87 2009 Long J.Z., Nomura D.K., Vann R.E., Walentiny D.M., Booker L., Jin X., Burston J.J., Sim-Selley L.J., Lichtman A.H., Wiley J.L., Cravatt B.F. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. (2009). Proc Natl Acad Sci. 106(48):20270-5. Varvel SA, Wise LE , Lichtman AH. (2009). Are CB1 Receptor Antagonists Nootropic or Cognitive Impairing Agents? Drug Development Research, 69:1-11. Booker L, Naidu PS, Razdan RK, Mahadevan A, Lichtman AH (2009). Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception. Drug Alcohol Depend. 105(1-2):42-7. Wise LE, Harloe JP, Lichtman AH. (2009). Fatty Acid Amide Hydrolase (FAAH) Knockout Mice Exhibit Enhanced Acquisition of an Aversive, but not of an Appetitive, Barnes Maze Task. Neurobiol Learn Mem. 92(4):597-601 Kinsey, S.G., Long, J.Z., O’Neal, S.T., Abdullah, R.A., Poklis, J.L., Boger, D., Cravatt, B.F. and Lichtman, A.H. (2009). Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. J Pharmacol Exp Ther. 330(3):902-10. Schlosburg, J.E., Carlson, B.L.A., Ramesh, D., Abdullah, R.A., Long, J.Z., Cravatt, B.F.,Lichtman, A.H.. (2009) Inhibitors of endocannabinoid metabolizing enzymes reduce precipitated withdrawal responses in THC dependent mice. AAPS Journal. 11(2):342-52. Wise LE , Thorpe AJ, Lichtman AH. (2009). Hippocampal CB 1 receptors mediate the memory impairing effects of delta 9 -tetrahydrocannabinol. Neuropsychopharmacology. 34(9):2072-80. Fowler CJ, Naidu PS, Lichtman A, Onnis V. (2009). The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1. Br J Pharmacol. 2009 Feb;156(3):412-9. Schlosburg, J.E., Kinsey, S.G., Lichtman, A.H. (2009). Targeting Fatty Acid Amide Hydrolase (FAAH) to Treat Pain and Inflammation. The AAPS Journal. Mar;11(1):39-44. Naidu, P.S., Booker, L, Cravatt, B.F., Lichtman, A.H. (2009). Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception. J Pharmacol Exp Ther.Apr;329(1):48-56. Schlosburg JE, Boger DL, Cravatt BF, Lichtman AH (2009). Endocannabinoid modulation of scratching response in an acute allergenic model: anew prospective neural therapeutic target for pruritus. J Pharmacol Exp Ther. Apr;329(1):314-23. Long, J.Z., Li, W, Booker, L, Burston, J.J., Kinsey, S.G., Schlosburg, J.E., Pavon, F.J., Serrano, A.M., Selley, D.E., Parsons, L.H., Lichtman, A.H., Cravatt, B.F. (2009). Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44. 2008 Harloe JP, Thorpe AJ, Lichtman AH (2008). Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks. Learn Mem. 15(11):806-9. Nomura DK, Hudak CS, Ward AM, Burston JJ, Issa RS, Fisher KJ, Abood ME, Wiley JL, Lichtman AH, Casida JE.(2008). Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Merritt LL, Martin BR, Walters C, Lichtman AH, Damaj MI (2008). The endogenous cannabinoid system modulates nicotine reward and dependence. J Pharmacol Exp Ther. 326(2):483-92. Wise LE, Iredale PA, Lichtman AH (2008). The cannabinoid CB(1) receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task. Eur J Pharmacol. 590(1-3):246-9. Oltmanns, M.H., Samudre, S.S., Castillo, I.G., Hosseini, A., Lichtman, A.H., Allen, R. C., Lattanzio Jr, F.A., Williams, P.B. (2008). Topical WIN55212-2 Alleviates Intraocular Hypertension in Rats Through a CB1 Receptor-Mediated Mechanism of Action. J Ocul Pharmacol Ther. 24(1):104-15. 2007 Wise, L.E., Lichtman, A.H. (2007). The uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist memantine prolongs spatial memory in a rat delayed radial-arm maze memory task. Eur J Pharmacol. 575, 98-102. Wise, L.E., Cannavacciulo, R., Cravatt, B.F., Martin, B.F., Lichtman, A.H. (2007). Evaluation of fatty acid amides in the carrageenan-induced paw edema model. Neuropharmacology. 2007 Jun 22; [Epub ahead of print] PMID: 17675189 [PubMed - as supplied by publisher] Niyuhire, F., Varvel, S.A., Martin, B.R., Lichtman, A.H.(2007). Exposure to marijuana smoke impairs memory retrieval in mice. J Pharmacol Exp Ther. 322, 1067-75. Varvel, S.A., Martin, B.R., Lichtman, A.H. (2007). Lack of behavioral sensitization after repeated exposure to THC in mice and comparison to methamphetamine. Psychopharmacology (Berl). 193, 511-9. Naidu,
P.S., Lichtman, A.H., Archer, C.C., May, E.L., Harris, L.S., Aceto, M.D. (2007).
NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension
test through a delta-opioid receptor mechanism of action. Eur J Pharmacol. 566,
132-6. Naidu, P.S., Varvel, S.A., Ahn, K., Cravatt, B.F., Martin, B.R., Lichtman, A.H. (2007). Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. Psychopharmacology (Berl). 192, 61-70 Pertwee, R.G., Thomas, A., Stevenson, L.A., Ross, R.A., Varvel, S.A., Lichtman, A.H., Martin, B.R., Razdan, R.K. (2007). The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo. Br J Pharmacol. 150, 586-94. Hoffman, A.F., Oz, M., Rang, R., Lichtman, A.H., Lupica, M.R. (2007) Opposing actions of chronic delta9-tetrahydrocananbinol and cannabinoid antagonists on hippocampal long-term potentiation, Learning and Memory, 14, 63-74. Wise, L.E., Shelton, C.C., Cravatt, B.F., Martin, B.R., and Lichtman, A.H. (2007) Assessment of anandamide’s pharmacological effects in mice deficient of both fatty acid amide hydrolase and CB1 receptors, European Journal of Pharmacology, 557, 44-48. Wise, L.E., Iredale, PA, Stokes, R.J. and Lichtman, A.H. (2007) Combination of rimonabant and donepezil enhances memory in a delayed radial arm maze task, Neuropsychopharmacology, advance online publication: DOI:10.1038/sj.npp.1301297. Niyuhire, F., Varvel, S.A. Thorpe, A.J., Stokes, R., Wiley, J.L., and Aron H. Lichtman, A.H. (2007) The disruptive effects of the CB1 receptor antagonist rimonabant in extinction learning are task specific, Psychopharmacology, 191, 223-231. Varvel, S.A., Wise, L.E., Niyuhire, F., Cravatt, B.F., Lichtman, A.H. (2007). Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology. 32,1032-41. 2006 Wilson, D.M., Bridgen, D.T., Varvel, S.A., Harloe, J., Martin, B.R., and Lichtman, A.H. (2006) SR 141716 (Rimonabant) Precipitates Withdrawal in Marijuana-dependent Mice, Pharmacology, Biochemistry and Behavior, 85, 105-113. Varvel, S.A., Wiley, J. Yang, R., Canavan, K, Lichtman, A.H., and Martin, B.R. (2006) Interactions between THC and Cannabidiol in mouse models of cannabinoid activity, Psychopharmacology, 186, 226-324. Varvel,
S.A., Engram, A., Cravatt, B.F., and Lichtman, A.H. (2006) Fatty acid amide
hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects
of anandamide or oleamide in a working memory water maze task, Journal of
Pharmacology and Experimental Therapeutics, 317, 251-257. 2005 Lichtman,
A.H. and Cravatt, B.F. (2005) Food for thought: endocannabinoid modulation of
lipogenesis, Journal of Clinical Investigation, 115, 1130-1133. Varvel, S.A., Bridgen, D.T., Qing, T, Thomas, B.F., Martin, B.R., Lichtman, A.H. (2005) Delta9-Tetrahydrocannabinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in mice, Journal of Pharmacology and Experimental Therapeutics, 314, 329-337. Varvel, S.A., Anum, E., and Lichtman, A.H. (2005) Blockade of the endocannabinoid system attenuates extinction in the Morris water maze, Psychopharmacology, 179, 863-872. Varvel, S.A., Anum, E., Niyuhire, F. Wise, L.E., and Lichtman, A.H. (2005) Delta9-THC-induced cognitive deficits in mice are reversed by the GABAA antagonist bicuculline, Psychopharmacology, 178, 317-327. 2004 Lichtman A.H., Leung, D., Shelton, C.C., Saghatelian, A., Hardouin, C., Boger, D.L., and Cravatt B.F. (2004) Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: Evidence for an unprecedented combination of potency and selectivity, Journal of Pharmacology and Experimental Therapeutics, 311, 441-448. Cravatt B.F. and Lichtman A.H. (2004) The endogenous cannabinoid system and its role in nociceptive behavior, Journal of Neurobiology, 61, 149-160. Cravatt
B.F., Saghatelian, A., Hawkins, E.G., Clement, A.B., and Bracey, M.H., and
Lichtman A.H. (2004) Functional Disassociation of the Central and Peripheral
Fatty Acid Amide Signaling System, Proceedings of the National Academy of
Sciences, 101, 10821-10826. Lichtman A.H., Shelton, C.C., Clement, A., Advani, T., and Cravatt, B.F. (2004) Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia, Pain. 109, 319-327. 2003 Mechoulam R. and Lichtman, A.H. (2003) Neuroscience Perspective: Stout guards of the central nervous system, Science, 302, 65-67. Cravatt B.F. and Lichtman A.H. (2003) Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system, Curr Opin Chem Biol., 7, 469-475. Clement
AB, Hawkins EG, Lichtman AH, Cravatt BF. (2003) Increased seizure susceptibility
and proconvulsant activity of anandamide in mice lacking fatty acid amide
hydrolase, J Neurosci., 23, 3916-23. 2002 Lichtman
A.H., Hawkins, G., Griffin, G., and Cravatt, B.F. (2002) Pharmacological activity
of fatty acid amides is regulated, but not mediated, by fatty acid amide
hydrolase in vivo,
Journal of Pharmacology and Experimental Therapeutics, 302, 73-79. Varvel,
S.A. and Lichtman, A.H. (2002) Evaluation of CB1 receptor knockout
mice in the Morris water maze, Journal of Pharmacology and Experimental
Therapeutics, 301, 915-924. Cravatt, B.F. and Lichtman, A.H. (2002) The Enzymatic Inactivation of the Fatty Acid Amide Class of Signaling Lipids, Chem Phys Lipid, 121:135-148. Wilson, D.M., Peart, J., Martin, B.R., Bridgen, D.T., Byron, P.R., Lichtman, A.H., (2002) Physiochemical and Pharmacological Characterization of a delta9-THC Aerosol Generated by a Metered Dose Inhaler. Drug and Alcohol Dependence. 67, 259-267. Lichtman, A.H., Varvel, S.A., and Martin, B.R. (2002) Endocannabinoids in Cognition and Dependence, Prostaglandins, Leukotrienes & Essential Fatty Acids, 66, 269-85. Lichtman, A.H. and Martin, B.R. (2002) Marijuana Withdrawal Syndrome in the Animal Model, J. Clin. Pharmacol. 42, 1S-18 2001 Cravatt, B.F., Demarest, K., Patricelli, M.P., Bracey, M.H., Giang, D.K., Martin, B.R., and Lichtman, A.H. (2001) Supersensitivity to Anandamide and Enhanced Endogenous Cannabinoid Signaling in Mice Lacking Fatty Acid Amide Hydrolase, Proceedings of the National Academy of Sciences, 98, 9371-9376. Lichtman,
A.H., Sheikh, S.M., Loh, H.H., and Martin, B.R. (2001) Opioid and cannabinoid
modulation of precipitated withdrawal in delta9-THC and
morphine-dependent mice, Journal of Pharmacology and Experimental Therapeutics,
298, 1007-1014. Varvel,
S.A., Hamm, R.J., Martin, B.R., and Lichtman, A.H. (2001) Differential effects
of delta9-THC on spatial reference and working memory in mice,
Psychopharmacology, 157, 142-50. O’Neal, C.L., Poklis, A., and Lichtman, A.H. (2001) Acetylcodeine, an impurity of illicitly manufactured heroin, elicits convulsions, antinociception, and locomotor stimulation in mice, Drug and Alcohol Dependence, 65, 37-43. Lichtman, A.H., Fisher, J., and Martin, B.R. (2001) Precipitated cannabinoid withdrawal is reversed by delta9-tetrahydrocannabinol or clonidine, Pharmacology Biochemistry and Behavior, 69, 181-188. Lichtman, A.H., Poklis, J.L., Poklis, A., Wilson, D,M., and Martin, B.R. (2001) The pharmacological activity of inhalation exposure to marijuana smoke in mice, Drug and Alcohol Dependence, 63, 107-116. 2000 Peart, J, Wilson, D,M., Lichtman, A.H., Martin, B.R., and Byron, P.R. (2000) Aerosolized delta9-tetrahyrdocannabinol (delta9-THC): An alternative to medical marijuana?, Respiratory Drug Delivery VII, 649-652. Lichtman, A.H. (2000) SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats, European Journal of Pharmacology, 404, 175-9. Lichtman, A.H., Peart, J., Poklis, J.L., Bridgen, D.T., Razdan, R.K., Wilson, D,M., Poklis, A., Meng, Y., Byron, P.R., and Martin, B.R. (2000) Pharmacological evaluation of aerosolized cannabinoids in mice, European Journal of Pharmacology, 399, 141-149. 1995-1999 Meng, Y., D. Troy Bridgen, Martin, B.R., and Lichtman, A.H. (1999) Pharmacological potency and biodisposition of methamphetamine via inhalation exposure in mice. Drug and Alcohol Dependence, 53, 111-120. Lichtman, A.H. (1999) Determining antinociceptive ED50 values through the up-and-down procedure: A reduction in animal use. Journal of Pharmacological and Toxicological Methods. 40, 81-85. Lichtman, A.H, Wiley, J.L., LaVecchia, K.L., Neviaser, S.T., Arthur, D.B., Wilson, D.M., and Martin, B.R. (1998) Acute and chronic cannabinoid effects: Characterization of precipitated withdrawal in dogs. European Journal of Pharmacology, 357, 139-148. Martin, B.R. and Lichtman, A.H. (1998) Cannabinoid transmission and pain transmission, Neurobiology of Disease, 5, 447-461. Lichtman, A.H. and Martin, B.R. (1997) The selective cannabinoid antagonist, SR 141716A, blocks cannabinoid-induced antinociception in rats. Pharmacology Biochemistry and Behavior, 57, 7-12. Meng, Y., Lichtman, A.H., Bridgen, D.T., and Martin, B.R. (1997) Inhalation studies with the drugs of abuse. in NIDA Research Monographs Series: Pharmacokinetics, metabolism, and pharmaceutics of drugs of abuse, 103, 201-224. Lichtman, A.H., Cook, S.A., and Martin, B.R. (1996) Investigation of brain sites mediating cannabinoid action: Evidence supporting periaqueductal gray involvement. Journal of Pharmacology and Experimental Therapeutics, 276: 585-593. Lichtman, A.H. and Martin, B.R. (1996) ∆9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism. Psychopharmacology, 126, 125-131. Lichtman, A.H., Meng, Y., and Martin, B.R. (1996) Inhalation exposure to volatilized opiates produces antinociception in mice. Journal of Pharmacology and Experimental Therapeutics, 279, 69-76. Meng, Y., Lichtman, A.H., D. Troy Bridgen, and Martin, B.R. (1996) Pharmacological potency and biodisposition of phencyclidine via inhalation exposure in mice. Drug and Alcohol Dependence, 43, 13-22. Wiley, J.L., Compton, D.R., Gordon, P.M., Siegel, C., Singer, M., Dutta, A., Lichtman, A.H., Balster, R.L., Razdan, R.K., and Martin, B.R. (1996) Evaluation of agonist-antagonist properties of nitrogen mustard and cyano derivatives of ∆8-tetrahydrocannabinol, Neuropharmacology, 35, 1793-1804. Cook, S.A., Welch, S.P., Lichtman, A.H., and Martin, B.R. (1995) Evaluation of c-AMP involvement in cannabinoid-induced antinociception. Life Sciences, 56, 2049-2056. Lichtman, A.H., Sathe, P., Dimen, K.R, and Martin, B.R. (1995) Acute tolerance to the cardiovascular effects of volatilized cocaine free base in rats. Drug and Alcohol Dependence, 38: 247-254.
Lichtman, A.H., Dimen, K.R., and Martin, B.R. (1995) Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology, 119, 282-290. Moore, K.A., Lichtman, A.H., Poklis, A., and Borzelleca, J.F. (1995) -Benzyl-N-Methyl-phenethylamine (BNMPA), an impurity of illicit methamphetamine synthesis: Pharmacological evaluation and interaction with methamphetamine. Drug and Alcohol Dependence, 39, 83-89. 1989-1994 Lichtman, A.H. and Martin, B.R. (1994) Changes in tail skin temperature are unlikely to be a confounding factor in the tail-flick test, Pain, 57, 257-258.
Lichtman, A.H., Smith, F.L. and Martin, B.R. (1993) Evidence that the antinociceptive tail-flick response is produced independently from changes in either tail-skin temperature or colonic temperature. Pain, 55, 283-295.
Lichtman, A.H. Smith, P.B., and Martin, B.R. (1992) The antinociceptive effects of intrathecally administered cannabinoids are influenced by lipophilicity, Pain, 51, 19-26
Lichtman, A.H. and Fanselow, M.S. (1991) Opioid and nonopioid conditional analgesia: The role of spinal opioid, noradrenergic, and serotonergic systems, Behavioral Neuroscience, 105, 658-669.
Lichtman, A.H. and Martin, B.R. (1991) Spinal and supraspinal components of cannabinoid-induced antinociception. Journal of Pharmacology and Experimental Therapeutics, 258, 517-523. Lichtman, A.H. and Martin, B.R. (1991) Cannabinoid-induced antinociception is mediated by a spinal alpha-2 noradrenergic mechanism. Brain Research, 559, 309-314. Borszcz, G.S., Lichtman, A.H., and Hughes, H.C. (1990) Comparison of escape and tail flick thresholds in the rat: A psychophysical analysis of morphine hypoalgesia, Physiology and Behavior, 47, 1017-1022. McLaughlin, C.R., Lichtman, A.H., Fanselow, M.S., and Cramer, C.P. (1990) Tonic nociception in neonatal rats. Pharmacology Biochemistry and Behavior, 36, 859-862. Bateman, S.T., Lichtman, A.H., and Cramer, C.P. (1990) Peripheral serotonergic inhibition of suckling. Pharmacology Biochemistry and Behavior, 37 219-225, 1990. Lichtman, A.H. and Fanselow, M.S. (1990) Cats produce analgesia in rats in the tail-flick test. Naltrexone sensitivity is determined by the nociceptive test stimulus. Brain Research, 533, 91-94.
Lichtman, A.H. and Cramer, C.P. (1989) Methysergide-induced nipple attachment depends upon suckling experience in juvenile rats. Behavioral Neuroscience, 103, 254-261. Lichtman, A.H. and Cramer, C.P. (1989) Relative importance of experience, social facilitation, and availability of milk in weaning of rats. Developmental Psychobiology, 22: 347-356. McLaughlin, C.R., Lichtman, A.H., Fanselow, M.S., and Cramer, C.P. (1989) Pro-Leu-Gly-NH2 serves as a conditioned stimulus in the acquisition of conditioned tolerance. Behavioral Neuroscience, 103, 447-451. McLaughlin, C.R., Lichtman, A.H., Pretlow, J.P., and Cramer, C.P. (1989) The ontogenesis of lithium-induced effects on suckling: Inhibition and facilitation. Developmental Psychobiology, 22, 803-815.
Publications | Book Chapters | PubMed Review Chapters and Monographs Welch, S.P., Lichtman, A.H., and Martin, B.R. (in press) Cannabinoids in Pain and Addiction, in: Pain and Chemical Dependency (Eds. H. Smith and S. Passik), Oxford University Press, NY. Lichtman, A.H. and Martin, B.R. (2006) Understanding the Pharmacology and Physiology of Cannabis Dependence, in: Cannabis Dependence Its Nature, Consequences and Treatment (Ed. J. Roffman and R. Stephens), Cambridge University Press, Cambridge UK, 37-57. Varvel, S.A. Lichtman, A.H. (2005) Role of the endocannabinoid system in learning and memory, in Cannabinoids as Therapeutics (Ed. R. Mechoulam), Birkhaeuser Publishing Ltd. Basel/Switzerland, 111-140. Lichtman, A.H. and Martin, B.R. (2005) Cannabinoid Tolerance and Dependence, in: Handbook of Experimental Pharmacology (Ed. R. Pertwee), Springer-Verlag, Heidelberg, 691-717. Varvel, S.A., Cichewicz, D.L., Lichtman, A.H. (2004) Interactions Between Cannabinoids and Opioids, in: Recent Advances on Pharmacology and Physiology of Cannabinoids (Ed. T. Wenger), Research Signpost, Keraka, India, 157-182. Selley, D.E., Lichtman, A.H. and Martin, B.R. (2002) Integration of Molecular and Behavioral Approaches to Evaluate Cannabinoid Dependence, in: Molecular Biology of Drug Addiction (Ed. R. Maldonado), Humana Press, Totowa, NJ, 199-220. Lichtman, A.H. and Martin, B.R. (1999) Analgesic properties of THC and its synthetic derivatives, in Marihuana and Medicine (Eds. G.G. Nahas, Sutin, and Agurell), Humana Press, 511-526. Martin, B.R. and Lichtman, A.H. (1998) Cannabinoid transmission and pain transmission, in The Neurobiology of Cannabinoid Transmission (Eds. R. Rodriguez de Fonseca and M. Navarro), Academic Press, 5, 447-461. Meng, Y., Lichtman, A.H., Bridgen, D.T., and Martin, B.R. (1997) Inhalation studies with the drugs of abuse, in NIDA Research Monographs Series: Pharmacokinetics, metabolism, and pharmaceutics of drugs of abuse, 103, 201-224. Compton, D.R., Harris, L.S., Lichtman, A.H., Martin, B.R. (1995) Marihuana, in Handbook of Experimental Pharmacology, Volume 118 Pharmacological Aspects of Drug Dependence-Toward an Integrated Neurobehavioral Approach (Eds. C.R. Schuster, S.W. Gust, and M.J. Kuhar), Springer Verlag, Heidelberg, 118, Chapt 5.
Lichtman, A.H. and Martin, B.R. (1990) Spinal action of cannabinoid-induced antinociception. Committee on the Problems of Drug Dependence 1990: Proceeding of the 52nd Annual Scientific Meeting, 105, 422-424, 1990.
Copyright © 2007-2011 Aron H.
Lichtman, Ph.D. All Rights Reserved. |
